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10.1002/jcp.24853 http://scihub22266oqcxt.onion/10.1002/jcp.24853 C4433473!4433473!25336320     free     free     free       J+Cell+Physiol 2015 ; 230 (6): 1170-80 Nephropedia Template TP {{tp|p=25336320|t=2015. Keeping Wnt Signalosome in Check by Vesicular Traffic |pdf=|usr=}}{{25336320}} gab.com Text Keeping Wnt Signalosome in Check by Vesicular Traffic JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25336320 #FOAvip Wg/Wnts are paracrine and autocrine ligands that activate distinct signaling pathways while being internalized through surface receptors. Converging and contrasting views are shaping our understanding of whether, where, and how endocytosis may modulate Wnt signaling. We gather considerable amount of evidences to elaborate the point that signal-receiving cells utilize distinct, flexible, and sophisticated vesicular trafficking mechanisms to keep Wnt signaling activity in check. Same molecules in a highly context-dependent fashion serve as regulatory hub for various signaling purposes: amplification, maintenance, inhibition, and termination. Updates are provided for the regulatory mechanisms related to the three critical cell surface complexes, Wnt-Fzd-LRP6, Dkk1-Kremen-LRP6, and R-spondin-LGR5-RNF43, which potently influence Wnt signaling. We pay particular attentions to how cells achieve sustained and delicate control of Wnt signaling strength by employing comprehensive aspects of vesicular trafficking. Twit Text FOAVip Keeping Wnt Signalosome in Check by Vesicular Traffic ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25336320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25336320 #FOAvip English Wikipedia <ref>{{Cite pmid|25336320}}</ref> Keeping Wnt Signalosome in Check by Vesicular Traffic #MMPMID25336320 FENG Q; GAO N J Cell Physiol 2015[Jun]; 230 (6): 1170-80 PMID25336320show ga Wg/Wnts are paracrine and autocrine ligands that activate distinct signaling pathways while being internalized through surface receptors. Converging and contrasting views are shaping our understanding of whether, where, and how endocytosis may modulate Wnt signaling. We gather considerable amount of evidences to elaborate the point that signal-receiving cells utilize distinct, flexible, and sophisticated vesicular trafficking mechanisms to keep Wnt signaling activity in check. Same molecules in a highly context-dependent fashion serve as regulatory hub for various signaling purposes: amplification, maintenance, inhibition, and termination. Updates are provided for the regulatory mechanisms related to the three critical cell surface complexes, Wnt-Fzd-LRP6, Dkk1-Kremen-LRP6, and R-spondin-LGR5-RNF43, which potently influence Wnt signaling. We pay particular attentions to how cells achieve sustained and delicate control of Wnt signaling strength by employing comprehensive aspects of vesicular trafficking. äKeeping Wnt Signalosome in Check by Vesicular Traffic (epmc).pdf DeepDyve Pubget Overpricing