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10.3892/ijo.2014.2551 http://scihub22266oqcxt.onion/10.3892/ijo.2014.2551 C4432716!4432716 !25050663     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25050663 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2014 ; 45 (4 ): 1457-68 Nephropedia Template TP {{tp|p=25050663 |t=2014. ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models |pdf=|usr=}}{{25050663 }} gab.com Text ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25050663 #FOAvip Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory cytokine, which possesses a contributing role in cancer progression and metastasis and, thus, is now considered a promising anticancer drug target. Many MIF-inactivating strategies have proven successful in delaying cancer growth. Here, we report on the synthesis of ISO-66, a novel, highly stable, small-molecule MIF inhibitor, an analog of ISO-1 with improved characteristics. The MIF:ISO-66 co-crystal structure demonstrated that ISO-66 ligates the tautomerase active site of MIF, which has previously been shown to play an important role in its biological functions. In vitro, ISO-66 enhanced specific and non-specific anticancer immune responses, whereas prolonged administration of ISO-66 in mice with established syngeneic melanoma or colon cancer was non-toxic and resulted in a significant decrease in tumor burden. Subsequent ex vivo analysis of mouse splenocytes revealed that the observed decrease in tumor growth rates was likely mediated by the selective in vivo expansion of antitumor-reactive effector cells induced by ISO-66. Compared to other MIF-inactivating strategies employed in vivo, the anticancer activity of ISO-66 is demonstrated to be of equal or better efficacy. Our findings suggest that targeting MIF, via highly specific and stable compounds, such as ISO-66, may be effective for cancer treatment and stimulation of anticancer immune responses. Twit Text FOAVip ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25050663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25050663 #FOAvip English Wikipedia <ref>{{Cite pmid|25050663 }}</ref> ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models #MMPMID25050663 Ioannou K ; Cheng KF ; Crichlow GV ; Birmpilis AI ; Lolis EJ ; Tsitsilonis OE ; Al-Abed Y Int J Oncol 2014[Oct]; 45 (4 ): 1457-68 PMID25050663 show ga Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory cytokine, which possesses a contributing role in cancer progression and metastasis and, thus, is now considered a promising anticancer drug target. Many MIF-inactivating strategies have proven successful in delaying cancer growth. Here, we report on the synthesis of ISO-66, a novel, highly stable, small-molecule MIF inhibitor, an analog of ISO-1 with improved characteristics. The MIF:ISO-66 co-crystal structure demonstrated that ISO-66 ligates the tautomerase active site of MIF, which has previously been shown to play an important role in its biological functions. In vitro, ISO-66 enhanced specific and non-specific anticancer immune responses, whereas prolonged administration of ISO-66 in mice with established syngeneic melanoma or colon cancer was non-toxic and resulted in a significant decrease in tumor burden. Subsequent ex vivo analysis of mouse splenocytes revealed that the observed decrease in tumor growth rates was likely mediated by the selective in vivo expansion of antitumor-reactive effector cells induced by ISO-66. Compared to other MIF-inactivating strategies employed in vivo, the anticancer activity of ISO-66 is demonstrated to be of equal or better efficacy. Our findings suggest that targeting MIF, via highly specific and stable compounds, such as ISO-66, may be effective for cancer treatment and stimulation of anticancer immune responses. |Animals [MESH] |Antineoplastic Agents/chemical synthesis/chemistry/*therapeutic use [MESH] |Catalytic Domain/drug effects [MESH] |Colonic Neoplasms/*drug therapy/immunology/pathology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Isoxazoles/chemical synthesis/chemistry/*therapeutic use [MESH] |Macrophage Migration-Inhibitory Factors/antagonists & inhibitors/chemistry [MESH] |Melanoma/*drug therapy/immunology/pathology [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasms, Experimental [MESH] |Phenols/chemical synthesis/chemistry/*therapeutic use [MESH] |Small Molecule Libraries/chemical synthesis/chemistry/*therapeutic use [MESH]ISO-66, a novel inhibitor of macrophage migration, shows efficacy in m(epmc).pdf DeepDyve Pubget Overpricing