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10.1074/jbc.M115.639021

http://scihub22266oqcxt.onion/10.1074/jbc.M115.639021
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C4432280!4432280!25795782
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suck abstract from ncbi


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pmid25795782      J+Biol+Chem 2015 ; 290 (20): 12595-602
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  • Systemic Lupus Erythematosus-associated Neutrophil Cytosolic Factor 2 Mutation Affects the Structure of NADPH Oxidase Complex* #MMPMID25795782
  • Armstrong DL; Eisenstein M; Zidovetzki R; Jacob CO
  • J Biol Chem 2015[May]; 290 (20): 12595-602 PMID25795782show ga
  • Background: Mutations in NCF2 predispose individuals to lupus.Results: NCF2 Arg-395 ? Trp is associated with lupus; Arg-395 stabilizes the C terminus of NCF4 and NCF2 loop 395?402.Conclusion: Trp-395 disrupts the NADPH oxidase complex.Significance: The results support a nuanced rather than strictly proinflammatory role for this pathway in immune regulation with important consequences for autoimmunity.
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