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10.1074/jbc.M115.642637

http://scihub22266oqcxt.onion/10.1074/jbc.M115.642637
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C4432274!4432274!25839234
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suck abstract from ncbi


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pmid25839234      J+Biol+Chem 2015 ; 290 (20): 12523-36
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  • Basophil-associated OX40 Ligand Participates in the Initiation of Th2 Responses during Airway Inflammation* #MMPMID25839234
  • Di C; Lin X; Zhang Y; Zhong W; Yuan Y; Zhou T; Liu J; Xia Z
  • J Biol Chem 2015[May]; 290 (20): 12523-36 PMID25839234show ga
  • Background: Basophils play a great role in the induction of Th2 cell responses in different disease contexts.Results: Basophils highly expressed OX40 ligand (OX40L) after activation. Adoptive transfer of activated basophils triggered a robust Th2 response and airway inflammation.Conclusion: Basophils primed Th2 responses via OX40-OX40L interaction in asthma.Significance: OX40L on basophils may be a novel therapeutic target in asthma.
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