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10.1074/jbc.M115.642637 http://scihub22266oqcxt.onion/10.1074/jbc.M115.642637 C4432274!4432274 !25839234     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25839234 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (20 ): 12523-36 Nephropedia Template TP {{tp|p=25839234 |t=2015. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation |pdf=|usr=}}{{25839234 }} gab.com Text Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25839234 #FOAvip Asthma is characterized by increased airway submucosal infiltration of T helper (Th) cells and myeloid cells that co-conspire to sustain a chronic inflammation. While recent studies have demonstrated that the myeloid basophils promote Th2 cells in response to various types of allergens, the underlying mechanisms are poorly understood. Here, we found for the first time that in a mouse model of allergic asthma basophils highly expressed OX40 ligand (OX40L) after activation. Interestingly, blockade of OX40-OX40L interaction suppressed basophils-primed Th2 cell differentiation in vitro and ameliorated ovalbumin (OVA)-induced allergic eosinophilic inflammation mediated by Th2 activation. In accordance, the adoptive transfer of basophils derived from mediastinal lymph nodes (MLN) of OVA-immunized mice triggered a robust Th2 response and eosinophilic inflammation in wild-type mice but largely muted in OX40(-/-) mice and mice receiving OX40L-blocked basophils. Taken together, our results reveal a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation. Twit Text FOAVip Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25839234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25839234 #FOAvip English Wikipedia <ref>{{Cite pmid|25839234 }}</ref> Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation #MMPMID25839234 Di C ; Lin X ; Zhang Y ; Zhong W ; Yuan Y ; Zhou T ; Liu J ; Xia Z J Biol Chem 2015[May]; 290 (20 ): 12523-36 PMID25839234 show ga Asthma is characterized by increased airway submucosal infiltration of T helper (Th) cells and myeloid cells that co-conspire to sustain a chronic inflammation. While recent studies have demonstrated that the myeloid basophils promote Th2 cells in response to various types of allergens, the underlying mechanisms are poorly understood. Here, we found for the first time that in a mouse model of allergic asthma basophils highly expressed OX40 ligand (OX40L) after activation. Interestingly, blockade of OX40-OX40L interaction suppressed basophils-primed Th2 cell differentiation in vitro and ameliorated ovalbumin (OVA)-induced allergic eosinophilic inflammation mediated by Th2 activation. In accordance, the adoptive transfer of basophils derived from mediastinal lymph nodes (MLN) of OVA-immunized mice triggered a robust Th2 response and eosinophilic inflammation in wild-type mice but largely muted in OX40(-/-) mice and mice receiving OX40L-blocked basophils. Taken together, our results reveal a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation. |Animals [MESH] |Asthma/genetics/*immunology/pathology/therapy [MESH] |Basophils/*immunology/pathology [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation/*immunology [MESH] |Membrane Glycoproteins/genetics/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |OX40 Ligand [MESH] |Th2 Cells/*immunology/pathology [MESH]Basophil-associated OX40 ligand participates in the initiation of Th2 (epmc).pdf DeepDyve Pubget Overpricing