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10.1128/AAC.00163-15 http://scihub22266oqcxt.onion/10.1128/AAC.00163-15 C4432207!4432207 !25845862     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25845862 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antimicrob+Agents+Chemother 2015 ; 59 (6 ): 3509-17 Nephropedia Template TP {{tp|p=25845862 |t=2015. Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U S hospitals (2011 to 2013) and characterization of ?-lactamase-producing strains |pdf=|usr=}}{{25845862 }} gab.com Text Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U S hospitals (2011 to 2013) and characterization of -lactamase-producing strains JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25845862 #FOAvip Ceftazidime-avibactam (MIC50/90, 0.12/0.25 ?g/ml) inhibited 99.9% (20,698/20,709) of Enterobacteriaceae isolates at ?8 ?g/ml. This compound was active against resistant subsets, including ceftazidime-nonsusceptible Enterobacter cloacae (MIC50/90, 0.25/0.5 ?g/ml) and extended-spectrum ?-lactamase (ESBL) phenotype isolates. An ESBL phenotype was noted among 12.4% (1,696/13,692 isolates from targeted species) of the isolates, including 776 Escherichia coli (12.0% for this species; MIC50/90, 0.12/0.25 ?g/ml), 721 Klebsiella pneumoniae (16.3%; MIC50/90, 0.12/0.25 ?g/ml), 119 Klebsiella oxytoca (10.3%; MIC50/90, 0.06/0.25 ?g/ml), and 80 Proteus mirabilis (4.9%; MIC50/90, 0.06/0.12 ?g/ml) isolates. The most common enzymes detected among ESBL phenotype isolates from 2013 (n = 743) screened using a microarray-based assay were CTX-M-15-like (n = 307), KPC (n = 120), SHV ESBLs (n = 118), and CTX-M-14-like (n = 110). KPC producers were highly resistant to comparators, and ceftazidime-avibactam (MIC50/90, 0.5/2 ?g/ml) and tigecycline (MIC50/90, 0.5/1 ?g/ml; 98.3% susceptible) were the most active agents against these strains. Meropenem (MIC50/90, ?0.06/?0.06 ?g/ml) and ceftazidime-avibactam (MIC50/90, 0.12/0.25 ?g/ml) were active against CTX-M-producing isolates. Other enzymes were also observed, and ceftazidime-avibactam displayed good activity against the isolates producing less common enzymes. Among 11 isolates displaying ceftazidime-avibactam MIC values of >8 ?g/ml, three were K. pneumoniae strains producing metallo-?-lactamases (all ceftazidime-avibactam MICs, >32 ?g/ml), with two NDM-1 producers and one K. pneumoniae strain carrying the bla(KPC-2) and bla(VIM-4) genes. Therapeutic options for isolates producing ?-lactamases may be limited, and ceftazidime-avibactam, which displayed good activity against strains, including those producing KPC enzymes, merits further study in infections where such organisms occur. Twit Text FOAVip Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U S hospitals (2011 to 2013) and characterization of -lactamase-producing strains ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25845862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25845862 #FOAvip English Wikipedia <ref>{{Cite pmid|25845862 }}</ref> Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U S hospitals (2011 to 2013) and characterization of ?-lactamase-producing strains #MMPMID25845862 Castanheira M ; Mills JC ; Costello SE ; Jones RN ; Sader HS Antimicrob Agents Chemother 2015[]; 59 (6 ): 3509-17 PMID25845862 show ga Ceftazidime-avibactam (MIC50/90, 0.12/0.25 ?g/ml) inhibited 99.9% (20,698/20,709) of Enterobacteriaceae isolates at ?8 ?g/ml. This compound was active against resistant subsets, including ceftazidime-nonsusceptible Enterobacter cloacae (MIC50/90, 0.25/0.5 ?g/ml) and extended-spectrum ?-lactamase (ESBL) phenotype isolates. An ESBL phenotype was noted among 12.4% (1,696/13,692 isolates from targeted species) of the isolates, including 776 Escherichia coli (12.0% for this species; MIC50/90, 0.12/0.25 ?g/ml), 721 Klebsiella pneumoniae (16.3%; MIC50/90, 0.12/0.25 ?g/ml), 119 Klebsiella oxytoca (10.3%; MIC50/90, 0.06/0.25 ?g/ml), and 80 Proteus mirabilis (4.9%; MIC50/90, 0.06/0.12 ?g/ml) isolates. The most common enzymes detected among ESBL phenotype isolates from 2013 (n = 743) screened using a microarray-based assay were CTX-M-15-like (n = 307), KPC (n = 120), SHV ESBLs (n = 118), and CTX-M-14-like (n = 110). KPC producers were highly resistant to comparators, and ceftazidime-avibactam (MIC50/90, 0.5/2 ?g/ml) and tigecycline (MIC50/90, 0.5/1 ?g/ml; 98.3% susceptible) were the most active agents against these strains. Meropenem (MIC50/90, ?0.06/?0.06 ?g/ml) and ceftazidime-avibactam (MIC50/90, 0.12/0.25 ?g/ml) were active against CTX-M-producing isolates. Other enzymes were also observed, and ceftazidime-avibactam displayed good activity against the isolates producing less common enzymes. Among 11 isolates displaying ceftazidime-avibactam MIC values of >8 ?g/ml, three were K. pneumoniae strains producing metallo-?-lactamases (all ceftazidime-avibactam MICs, >32 ?g/ml), with two NDM-1 producers and one K. pneumoniae strain carrying the bla(KPC-2) and bla(VIM-4) genes. Therapeutic options for isolates producing ?-lactamases may be limited, and ceftazidime-avibactam, which displayed good activity against strains, including those producing KPC enzymes, merits further study in infections where such organisms occur. |Azabicyclo Compounds/*pharmacology [MESH] |Ceftazidime/*pharmacology [MESH] |Enterobacteriaceae/*drug effects/*metabolism [MESH] |Escherichia coli/drug effects/metabolism [MESH] |Klebsiella oxytoca/drug effects/metabolism [MESH] |Klebsiella pneumoniae/drug effects/metabolism [MESH] |Microbial Sensitivity Tests [MESH] |Proteus mirabilis/drug effects/metabolism [MESH] |United States [MESH]Ceftazidime-avibactam activity tested against Enterobacteriaceae isola(epmc).pdf DeepDyve Pubget Overpricing