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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Antimicrob+Agents+Chemother
2015 ; 59
(6
): 3529-40
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Commensal streptococci serve as a reservoir for ?-lactam resistance genes in
Streptococcus pneumoniae
#MMPMID25845880
Jensen A
; Valdórsson O
; Frimodt-Møller N
; Hollingshead S
; Kilian M
Antimicrob Agents Chemother
2015[]; 59
(6
): 3529-40
PMID25845880
show ga
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia,
and middle ear infections. The incidence of S. pneumoniae isolates that are not
susceptible to penicillin has risen worldwide and may be above 20% in some
countries. Beta-lactam antibiotic resistance in pneumococci is associated with
significant sequence polymorphism in penicillin-binding proteins (PBPs).
Commensal streptococci, especially S. mitis and S. oralis, have been identified
as putative donors of mutated gene fragments. However, no studies have compared
sequences of the involved pbp genes in large collections of commensal
streptococci with those of S. pneumoniae. We therefore investigated the sequence
diversity of the transpeptidase region of the three pbp genes, pbp2x, pbp2b, and
pbp1a in 107, 96, and 88 susceptible and nonsusceptible strains of commensal
streptococci, respectively, at the nucleotide and amino acid levels to determine
to what extent homologous recombination between commensal streptococci and S.
pneumoniae plays a role in the development of beta-lactam resistance in S.
pneumoniae. In contrast to pneumococci, extensive sequence variation in the
transpeptidase region of pbp2x, pbp2b, and pbp1a was observed in both susceptible
and nonsusceptible strains of commensal streptococci, conceivably reflecting the
genetic diversity of the many evolutionary lineages of commensal streptococci
combined with the recombination events occurring with intra- and interspecies
homologues. Our data support the notion that resistance to beta-lactam
antibiotics in pneumococci is due to sequences acquired from commensal Mitis
group streptococci, especially S. mitis. However, several amino acid alterations
previously linked to beta-lactam resistance in pneumococci appear to represent
species signatures of the donor strain rather than being causal of resistance.
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