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10.1128/AAC.00364-15

http://scihub22266oqcxt.onion/10.1128/AAC.00364-15
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C4432173!4432173!25824208
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suck abstract from ncbi


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pmid25824208      Antimicrob+Agents+Chemother 2015 ; 59 (6): 3623-6
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  • In Vitro Activity of Ceftazidime-Avibactam against 338 Molecularly Characterized Gentamicin-Nonsusceptible Gram-Negative Clinical Isolates Obtained from Patients in Canadian Hospitals #MMPMID25824208
  • Denisuik AJ; Karlowsky JA; Denisuik T; Nichols WW; Keating TA; Adam HJ; Baxter M; Walkty A; Zhanel GG
  • Antimicrob Agents Chemother 2015[Jun]; 59 (6): 3623-6 PMID25824208show ga
  • The mechanism of aminoglycoside resistance among 338 gentamicin-nonsusceptible Gram-negative bacteria (207 Enterobacteriaceae and 131 Pseudomonas aeruginosa) was assessed, and the in vitro activity of ceftazidime-avibactam against these isolates was determined. Aminoglycoside-modifying enzymes were detected in 91.8% of Enterobacteriaceae and 13.7% of P. aeruginosa isolates. A single strain of Klebsiella pneumoniae harbored a 16S rRNA methylase (ArmA). The ceftazidime-avibactam MIC90 values were 0.5 ?g/ml (MIC, ?8 ?g/ml for 100% of isolates) and 16 ?g/ml (MIC, ?8 ?g/ml for 87.8% of isolates) against gentamicin-nonsusceptible Enterobacteriaceae and P. aeruginosa isolates, respectively.
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