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10.1128/AAC.00171-15

http://scihub22266oqcxt.onion/10.1128/AAC.00171-15
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C4432126!4432126!25824227
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suck abstract from ncbi


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pmid25824227      Antimicrob+Agents+Chemother 2015 ; 59 (6): 3630-2
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  • Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis #MMPMID25824227
  • Davies Forsman L; Giske CG; Bruchfeld J; Schön T; Juréen P; Ängeby K
  • Antimicrob Agents Chemother 2015[Jun]; 59 (6): 3630-2 PMID25824227show ga
  • We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.
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