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2015 ; 59
(6
): 3637-40
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Efficacy of tigecycline for secondary Acinetobacter bacteremia and factors
associated with treatment failure
#MMPMID25824230
Liou BH
; Lee YT
; Kuo SC
; Liu PY
; Fung CP
Antimicrob Agents Chemother
2015[]; 59
(6
): 3637-40
PMID25824230
show ga
We describe the clinical outcome of 17 patients with secondary Acinetobacter
bacteremia whose isolates had a tigecycline MIC of ?2 mg/liter and who received
tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the
tigecycline cohort was 41.2% (7/17), which was significantly higher than that of
those receiving other appropriate antimicrobial agents (13.8%, 9/65; P = 0.018).
However, the percentages of end-stage renal disease and congestive heart failure
were higher in the tigecycline cohort. The efficacy of tigecycline was contingent
upon the illness severity and bacterial species. Tigecycline should be applied
cautiously for treatment of Acinetobacter bacteremia.