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10.1016/j.devcel.2015.03.015 http://scihub22266oqcxt.onion/10.1016/j.devcel.2015.03.015 C4431772!4431772 !25898168     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25898168 &cmd=llinks): Failed to open stream: HTTP request failed! 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Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane |pdf=|usr=}}{{25898168 }} gab.com Text Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25898168 #FOAvip In metazoans, cytokinesis is triggered by activation of the GTPase RhoA at the equatorial plasma membrane. ECT-2, the guanine nucleotide exchange factor (GEF) required for RhoA activation, is activated by the centralspindlin complex that concentrates on spindle midzone microtubules. However, these microtubules and the plasma membrane are not generally in apposition, and thus the mechanism by which RhoA is activated at the cell equator remains unknown. Here we report that a regulated pool of membrane-bound, oligomeric centralspindlin stimulates RhoA activation. The membrane-binding C1 domain of CYK-4, a centralspindlin component, promotes furrow initiation in C. elegans embryos and human cells. Membrane localization of centralspindlin oligomers is globally inhibited by PAR-5/14-3-3. This activity is antagonized by the chromosome passenger complex (CPC), resulting in RhoA activation at the nascent cleavage site. Therefore, CPC-directed centralspindlin oligomerization during anaphase induces contractile ring assembly at the membrane. Twit Text FOAVip Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25898168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25898168 #FOAvip English Wikipedia <ref>{{Cite pmid|25898168 }}</ref> Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane #MMPMID25898168 Basant A ; Lekomtsev S ; Tse YC ; Zhang D ; Longhini KM ; Petronczki M ; Glotzer M Dev Cell 2015[Apr]; 33 (2 ): 204-15 PMID25898168 show ga In metazoans, cytokinesis is triggered by activation of the GTPase RhoA at the equatorial plasma membrane. ECT-2, the guanine nucleotide exchange factor (GEF) required for RhoA activation, is activated by the centralspindlin complex that concentrates on spindle midzone microtubules. However, these microtubules and the plasma membrane are not generally in apposition, and thus the mechanism by which RhoA is activated at the cell equator remains unknown. Here we report that a regulated pool of membrane-bound, oligomeric centralspindlin stimulates RhoA activation. The membrane-binding C1 domain of CYK-4, a centralspindlin component, promotes furrow initiation in C. elegans embryos and human cells. Membrane localization of centralspindlin oligomers is globally inhibited by PAR-5/14-3-3. This activity is antagonized by the chromosome passenger complex (CPC), resulting in RhoA activation at the nascent cleavage site. Therefore, CPC-directed centralspindlin oligomerization during anaphase induces contractile ring assembly at the membrane. |Animals [MESH] |Aurora Kinase B/genetics/*metabolism [MESH] |Caenorhabditis elegans Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Caenorhabditis elegans/*embryology [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/metabolism [MESH] |Cytokinesis/*genetics [MESH] |Guanine Nucleotide Exchange Factors/metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Microtubules/metabolism [MESH] |Protein Multimerization [MESH] |Protein Structure, Tertiary [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH] |Spindle Apparatus/genetics [MESH]Aurora B kinase promotes cytokinesis by inducing centralspindlin oligo(epmc).pdf DeepDyve Pubget Overpricing