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10.12688/f1000research.6400.1 http://scihub22266oqcxt.onion/10.12688/f1000research.6400.1 C4431381!4431381!26069731     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2015 ; 4 (ä): ä Nephropedia Template TP {{tp|p=26069731|t=2015. The ? NF-?B interacting long noncoding RNA? ( NKILA) transcript is antisense to cancer-associated gene PMEPA1 |pdf=|usr=}}{{26069731}} gab.com Text The NF- B interacting long noncoding RNA ( NKILA) transcript is antisense to cancer-associated gene PMEPA1 JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26069731 #FOAvip This correspondence concerns a recent publication in Cancer Cell by Liu et al. 1 who analyzed a long noncoding RNA (lncRNA) that they designated ? NKILA?. Liu et al. found that NKILA (1)  is upregulated by immunostimulants, (2) has a promoter with an NF-?B binding motif, (3) can bind to the p65 protein of the NF-?B transcription factor and then interfere with phosphorylation of I?B?, and (4) negatively affects functions that involve NF-?B pathways.  And, importantly, they found that (5) low NKILA expression in breast cancers is associated with poor patient prognosis.  However, they entirely failed to mention PMEPA1, a gene which runs antisense to NKILA, and the expression of which is associated with several tumors and which encodes a protein that participates in immune pathways.The PMEPA1 locus, including its promoter region, which Liu et al. 1 only discuss in regard to NKILA, is highly conserved through evolution.  Our impression is that NKILA emerged only later in evolution, possibly as an additional means of PMEPA1 regulation.  Liu et al., however, only consider direct binding between NKILA and NF-?B as the mechanism for their in vivo observations of NKILA function, but do not provide solid evidence for their model.  If in vivo observations by Liu et al. could be explained by NKILA regulation of PMEPA1, it would contribute to the establishment of PMEPA1 as an important topic of cancer research.  We feel that the herein presented discussion is necessary for a correct interpretation of the Liu et al. article. Twit Text FOAVip The NF- B interacting long noncoding RNA ( NKILA) transcript is antisense to cancer-associated gene PMEPA1 ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=26069731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26069731 #FOAvip English Wikipedia <ref>{{Cite pmid|26069731}}</ref> The ? NF-?B interacting long noncoding RNA? ( NKILA) transcript is antisense to cancer-associated gene PMEPA1 #MMPMID26069731 Dijkstra JM; Alexander DB F1000Res 2015[]; 4 (ä): ä PMID26069731show ga This correspondence concerns a recent publication in Cancer Cell by Liu et al. 1 who analyzed a long noncoding RNA (lncRNA) that they designated ? NKILA?. Liu et al. found that NKILA (1)  is upregulated by immunostimulants, (2) has a promoter with an NF-?B binding motif, (3) can bind to the p65 protein of the NF-?B transcription factor and then interfere with phosphorylation of I?B?, and (4) negatively affects functions that involve NF-?B pathways.  And, importantly, they found that (5) low NKILA expression in breast cancers is associated with poor patient prognosis.  However, they entirely failed to mention PMEPA1, a gene which runs antisense to NKILA, and the expression of which is associated with several tumors and which encodes a protein that participates in immune pathways.The PMEPA1 locus, including its promoter region, which Liu et al. 1 only discuss in regard to NKILA, is highly conserved through evolution.  Our impression is that NKILA emerged only later in evolution, possibly as an additional means of PMEPA1 regulation.  Liu et al., however, only consider direct binding between NKILA and NF-?B as the mechanism for their in vivo observations of NKILA function, but do not provide solid evidence for their model.  If in vivo observations by Liu et al. could be explained by NKILA regulation of PMEPA1, it would contribute to the establishment of PMEPA1 as an important topic of cancer research.  We feel that the herein presented discussion is necessary for a correct interpretation of the Liu et al. article. äThe ? NF-?B interacting long noncoding RNA? ( NKILA) transcript is ant(epmc).pdf DeepDyve Pubget Overpricing