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2015 ; 2015
(ä): 424381
Nephropedia Template TP
gab.com Text
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English Wikipedia
Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data
to Differentiate Macrophage Activation Syndrome from Active Disease
#MMPMID26063955
Assari R
; Ziaee V
; Mirmohammadsadeghi A
; Moradinejad MH
Dis Markers
2015[]; 2015
(ä): 424381
PMID26063955
show ga
PURPOSE: To compare the laboratory data and changes in these data between
patients with MAS and patients with flare-up of the autoimmune diseases. METHODS:
In a prospective study, the static laboratory data and dynamic changes in the
selected data in 17 consecutive patients with MAS and 53 patients with active
disease of SJIA, PJIA, Kawasaki disease, and SLE were compared. The ROC curve
analysis was used to evaluate cut-off points, sensitivity, and specificity of the
static and dynamic laboratory data to differentiate between MAS and active
disease. RESULTS: In the MAS group, the mean CRP3, ALT, AST, total bilirubin,
ferritin, LDH, PT, PTT, and INR were significantly higher and the mean WBC2,
PMN2, Lymph2, Hgb1, 2, 3, ESR2, serum albumin, and sodium were significantly
lower than in control group. Some of the important cut-off points were PLT2 <
209000/microliter, AST > 38.5, ALT > 38, WBC < 8200 × 103/UL, ferritin > 5277
ng/mL. CONCLUSION: The dynamic changes in some laboratory data, especially PLT,
can differentiate between MAS and active disease. The changes in WBC, PMN, and
ESR and the levels of the liver enzymes may also be helpful in the early
differentiation. Very high levels of ferritin may also help the diagnosis along
with other clinical and laboratory signs.