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10.1016/j.taap.2015.03.027 http://scihub22266oqcxt.onion/10.1016/j.taap.2015.03.027 C4430411!4430411 !25868844     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25868844 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Toxicol+Appl+Pharmacol 2015 ; 285 (2 ): 110-7 Nephropedia Template TP {{tp|p=25868844 |t=2015. Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells |pdf=|usr=}}{{25868844 }} gab.com Text Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells JO: Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25868844 #FOAvip Secretion of inorganic mercury (Hg(2+)) from proximal tubular cells into the tubular lumen has been shown to involve the multidrug resistance-associated protein 2 (Mrp2). Considering similarities in localization and substrate specificity between Mrp2 and the breast cancer resistance protein (Bcrp), we hypothesize that Bcrp may also play a role in the proximal tubular secretion of mercuric species. In order to test this hypothesis, the uptake of Hg(2+) was examined initially using inside-out membrane vesicles containing Bcrp. The results of these studies suggest that Bcrp may be capable of transporting certain conjugates of Hg(2+). To further characterize the role of Bcrp in the handling of mercuric ions and in the induction of Hg(2+)-induced nephropathy, Sprague-Dawley and Bcrp knockout (bcrp(-/-)) rats were exposed intravenously to a non-nephrotoxic (0.5 ?mol · kg(-1)), a moderately nephrotoxic (1.5 ?mol · kg(-1)) or a significantly nephrotoxic (2.0 ?mol · kg(-1)) dose of HgCl2. In general, the accumulation of Hg(2+) was greater in organs of bcrp(-/-) rats than in Sprague-Dawley rats, suggesting that Bcrp may play a role in the export of Hg(2+) from target cells. Within the kidney, cellular injury and necrosis was more severe in bcrp(-/-) rats than in controls. The pattern of necrosis, which was localized in the inner cortex and the outer stripe of the outer medulla, was significantly different from that observed in Mrp2-deficient animals. These findings suggest that Bcrp may be involved in the cellular export of select mercuric species and that its role in this export may differ from that of Mrp2. Twit Text FOAVip Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells ????Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25868844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25868844 #FOAvip English Wikipedia <ref>{{Cite pmid|25868844 }}</ref> Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells #MMPMID25868844 Bridges CC ; Zalups RK ; Joshee L Toxicol Appl Pharmacol 2015[Jun]; 285 (2 ): 110-7 PMID25868844 show ga Secretion of inorganic mercury (Hg(2+)) from proximal tubular cells into the tubular lumen has been shown to involve the multidrug resistance-associated protein 2 (Mrp2). Considering similarities in localization and substrate specificity between Mrp2 and the breast cancer resistance protein (Bcrp), we hypothesize that Bcrp may also play a role in the proximal tubular secretion of mercuric species. In order to test this hypothesis, the uptake of Hg(2+) was examined initially using inside-out membrane vesicles containing Bcrp. The results of these studies suggest that Bcrp may be capable of transporting certain conjugates of Hg(2+). To further characterize the role of Bcrp in the handling of mercuric ions and in the induction of Hg(2+)-induced nephropathy, Sprague-Dawley and Bcrp knockout (bcrp(-/-)) rats were exposed intravenously to a non-nephrotoxic (0.5 ?mol · kg(-1)), a moderately nephrotoxic (1.5 ?mol · kg(-1)) or a significantly nephrotoxic (2.0 ?mol · kg(-1)) dose of HgCl2. In general, the accumulation of Hg(2+) was greater in organs of bcrp(-/-) rats than in Sprague-Dawley rats, suggesting that Bcrp may play a role in the export of Hg(2+) from target cells. Within the kidney, cellular injury and necrosis was more severe in bcrp(-/-) rats than in controls. The pattern of necrosis, which was localized in the inner cortex and the outer stripe of the outer medulla, was significantly different from that observed in Mrp2-deficient animals. These findings suggest that Bcrp may be involved in the cellular export of select mercuric species and that its role in this export may differ from that of Mrp2. |ATP Binding Cassette Transporter, Subfamily G, Member 2 [MESH] |ATP-Binding Cassette Transporters/genetics/*metabolism [MESH] |Animals [MESH] |Blood Urea Nitrogen [MESH] |Creatinine/blood [MESH] |Feces/chemistry [MESH] |Gene Knockout Techniques [MESH] |Kidney Tubules, Proximal/cytology/*metabolism [MESH] |Kidney/*metabolism/pathology [MESH] |Liver/metabolism [MESH] |Male [MESH] |Membranes/metabolism [MESH] |Mercuric Chloride/metabolism/toxicity [MESH] |Mercury Compounds/*metabolism/urine [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Toxicological significance of renal Bcrp: Another potential transporte(epmc).pdf DeepDyve Pubget Overpricing