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10.1038/ncomms7931 http://scihub22266oqcxt.onion/10.1038/ncomms7931 C4430126!4430126 !25959047     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25959047 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 6931 Nephropedia Template TP {{tp|p=25959047 |t=2015. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation |pdf=|usr=}}{{25959047 }} gab.com Text Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25959047 #FOAvip Interstitial osmolality is a key homeostatic variable that varies depending on the tissue microenvironment. Mammalian cells have effective mechanisms to cope with osmotic stress by engaging various adaptation responses. Hyperosmolality due to high dietary salt intake has been linked to pathological inflammatory conditions. Little is known about the mechanisms of sensing the hyperosmotic stress by the innate immune system. Here we report that caspase-1 is activated in macrophages under hypertonic conditions. Mice with high dietary salt intake display enhanced induction of Th17 response upon immunization, and this effect is abolished in caspase-1-deficient mice. Our findings identify an unknown function of the inflammasome as a sensor of hyperosmotic stress, which is crucial for the induction of inflammatory Th17 response. Twit Text FOAVip Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25959047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25959047 #FOAvip English Wikipedia <ref>{{Cite pmid|25959047 }}</ref> Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation #MMPMID25959047 Ip WK ; Medzhitov R Nat Commun 2015[May]; 6 (ä): 6931 PMID25959047 show ga Interstitial osmolality is a key homeostatic variable that varies depending on the tissue microenvironment. Mammalian cells have effective mechanisms to cope with osmotic stress by engaging various adaptation responses. Hyperosmolality due to high dietary salt intake has been linked to pathological inflammatory conditions. Little is known about the mechanisms of sensing the hyperosmotic stress by the innate immune system. Here we report that caspase-1 is activated in macrophages under hypertonic conditions. Mice with high dietary salt intake display enhanced induction of Th17 response upon immunization, and this effect is abolished in caspase-1-deficient mice. Our findings identify an unknown function of the inflammasome as a sensor of hyperosmotic stress, which is crucial for the induction of inflammatory Th17 response. |Animals [MESH] |Apoptosis Regulatory Proteins/*metabolism [MESH] |Calcium-Binding Proteins/*metabolism [MESH] |Carrier Proteins/*metabolism [MESH] |Caspase 1/metabolism [MESH] |Enzyme Activation [MESH] |Inflammasomes/*metabolism [MESH] |Inflammation/*metabolism/*pathology [MESH] |Interleukin-1beta/metabolism [MESH] |Macrophages/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mitochondria/metabolism [MESH] |Mitophagy [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Osmolar Concentration [MESH] |Osmotic Pressure [MESH] |Reactive Oxygen Species/metabolism [MESH] |Sodium Chloride, Dietary [MESH]Macrophages monitor tissue osmolarity and induce inflammatory response(epmc).pdf DeepDyve Pubget Overpricing