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10.1016/j.molcel.2014.07.012 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.07.012 C4428586!4428586!25155612     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2014 ; 55 (5): 791-802 Nephropedia Template TP {{tp|p=25155612|t=2014. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites |pdf=|usr=}}{{25155612}} gab.com Text The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25155612 #FOAvip Mechanistic roles for many lncRNAs are poorly understood in part because their direct interactions with genomic loci and proteins are difficult to assess. Using a method to purify endogenous RNAs and their associated factors, we mapped the genomic binding sites for two highly expressed human lncRNAs, NEAT1 and MALAT1. We show that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes. NEAT1 and MALAT1 exhibit colocalization to many of these loci, but display distinct gene body binding patterns at these sites, suggesting independent but complementary functions for these RNAs. We also identified numerous proteins enriched by both lncRNAs, supporting complementary binding and function, in addition to unique associated proteins. Transcriptional inhibition or stimulation alters localization of NEAT1 on active chromatin sites, implying that underlying DNA sequence does not target NEAT1 to chromatin and that localization responds to cues involved in the transcription process. Twit Text FOAVip The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25155612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25155612 #FOAvip English Wikipedia <ref>{{Cite pmid|25155612}}</ref> The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites #MMPMID25155612 West JA; Davis CP; Sunwoo H; Simon MD; Sadreyev RI; Wang PI; Tolstorukov MY; Kingston RE Mol Cell 2014[Sep]; 55 (5): 791-802 PMID25155612show ga Mechanistic roles for many lncRNAs are poorly understood in part because their direct interactions with genomic loci and proteins are difficult to assess. Using a method to purify endogenous RNAs and their associated factors, we mapped the genomic binding sites for two highly expressed human lncRNAs, NEAT1 and MALAT1. We show that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes. NEAT1 and MALAT1 exhibit colocalization to many of these loci, but display distinct gene body binding patterns at these sites, suggesting independent but complementary functions for these RNAs. We also identified numerous proteins enriched by both lncRNAs, supporting complementary binding and function, in addition to unique associated proteins. Transcriptional inhibition or stimulation alters localization of NEAT1 on active chromatin sites, implying that underlying DNA sequence does not target NEAT1 to chromatin and that localization responds to cues involved in the transcription process. äThe long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites (epmc).pdf DeepDyve Pubget Overpricing