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2015 ; 30
(5
): 604-13
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Paraphilias and paraphilic disorders in Parkinson s disease: A systematic review
of the literature
#MMPMID25759330
Solla P
; Bortolato M
; Cannas A
; Mulas CS
; Marrosu F
Mov Disord
2015[Apr]; 30
(5
): 604-13
PMID25759330
show ga
Paraphilias are intense urges or behaviors involving non-normative sexual
interests. The newly approved diagnostic criteria in the Diagnostic and
Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) have established
that, although paraphilias should not be regarded as inherently pathological,
they ought to be qualified as paraphilic disorders if resulting in distress,
impairment, or harm to the affected individual or others. Recent evidence
documents that both phenomena can emerge as relatively uncommon iatrogenic
consequences in Parkinson's disease (PD) patients. To outline the clinical
characteristics of paraphilias and paraphilic disorders in PD patients, we
summarized the available evidence on these phenomena. The review encompasses all
studies on paraphilias in PD patients identified by a search on the Pubmed and
Scopus online databases through May 2014. Twenty-two case reports on a total of
31 PD patients with paraphilias or paraphilic disorders were identified. These
phenomena were typically associated with dopaminomimetic treatment (with a mean
levodopa-equivalent daily dose of 1,303?±?823 mg/d) in male patients with motor
complications, young age at PD onset, and long disease duration. Paraphilias were
highly concomitant with impulse-control disorders or dopamine dysregulation
syndrome. Although evidence on paraphilias and paraphilic disorders in PD
patients remains anecdotal, available data point to these phenomena as likely
sequelae of high-dose dopaminomimetic treatment. Accordingly, the intensity of
paraphilic urges is typically attenuated by the reduction of dopaminomimetic
doses, sometimes in association with atypical antipsychotics. Failure to
recognize paraphilic disorders may significantly impair the relational
functioning of the affected PD patients. Practitioners should routinely inquire
about paraphilias during their clinical assessment of PD patients.
|Antiparkinson Agents/*adverse effects
[MESH]
|Databases, Bibliographic/statistics & numerical data
[MESH]