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10.15252/embr.201540096 http://scihub22266oqcxt.onion/10.15252/embr.201540096 C4428049!4428049!25770130     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2015 ; 16 (5): 638-53 Nephropedia Template TP {{tp|p=25770130|t=2015. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing ??T cells |pdf=|usr=}}{{25770130}} gab.com Text The thymic cortical epithelium determines the TCR repertoire of IL-17-producing T cells JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25770130 #FOAvip The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a massive loss of thymic cellularity and impaired the development of ??T cells and invariant natural killer T cells. Unexpectedly, the differentiation of certain ??T-cell subpopulations?interleukin-17-producing V?4 and V?6 cells?was strongly dysregulated, resulting in the perturbation of ??T-mediated inflammatory responses in peripheral tissues. These findings show that cTECs contribute to the shaping of the TCR repertoire, not only of ?conventional? ??T cells but also of inflammatory ?innate? ??T cells. Twit Text FOAVip The thymic cortical epithelium determines the TCR repertoire of IL-17-producing T cells ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25770130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25770130 #FOAvip English Wikipedia <ref>{{Cite pmid|25770130}}</ref> The thymic cortical epithelium determines the TCR repertoire of IL-17-producing ??T cells #MMPMID25770130 Nitta T; Muro R; Shimizu Y; Nitta S; Oda H; Ohte Y; Goto M; Yanobu-Takanashi R; Narita T; Takayanagi H; Yasuda H; Okamura T; Murata S; Suzuki H EMBO Rep 2015[May]; 16 (5): 638-53 PMID25770130show ga The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a massive loss of thymic cellularity and impaired the development of ??T cells and invariant natural killer T cells. Unexpectedly, the differentiation of certain ??T-cell subpopulations?interleukin-17-producing V?4 and V?6 cells?was strongly dysregulated, resulting in the perturbation of ??T-mediated inflammatory responses in peripheral tissues. These findings show that cTECs contribute to the shaping of the TCR repertoire, not only of ?conventional? ??T cells but also of inflammatory ?innate? ??T cells. äThe thymic cortical epithelium determines the TCR repertoire of IL-17-(epmc).pdf DeepDyve Pubget Overpricing