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10.2174/1570159X12666140923210929 http://scihub22266oqcxt.onion/10.2174/1570159X12666140923210929 C4428028!4428028!25977681     free     free     free       Curr+Neuropharmacol 2014 ; 12 (6): 564-74 Nephropedia Template TP {{tp|p=25977681|t=2014. The Many Roles of Statins in Ischemic Stroke |pdf=|usr=}}{{25977681}} gab.com Text The Many Roles of Statins in Ischemic Stroke JO: Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25977681 #FOAvip Stroke is the third leading cause of human death. Endothelial dysfunction, thrombogenesis, inflammatory and oxidative stress damage, and angiogenesis play an important role in cerebral ischemic pathogenesis and represent a target for prevention and treatment. Statins have been found to improve endothelial function, modulate thrombogenesis, attenuate inflammatory and oxidative stress damage, and facilitate angiogenesis far beyond lowering cholesterol levels. Statins have also been proved to significantly decrease cardiovascular risk and to improve clinical outcome. Could statins be the new candidate agent for the prevention and therapy in ischemic stroke? In recent years, a vast expansion in the understanding of the pathophysiology of ischemic stroke and the pleiotropic effects of statins has occurred and clinical trials involving statins for the prevention and treatment of ischemic stroke have begun. These facts force us to revisit ischemic stroke and consider new strategies for prevention and treatment. Here, we survey the important developments in the non-lipid dependent pleiotropic effects and clinical effects of statins in ischemic stroke. Twit Text FOAVip The Many Roles of Statins in Ischemic Stroke ????Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25977681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25977681 #FOAvip English Wikipedia <ref>{{Cite pmid|25977681}}</ref> The Many Roles of Statins in Ischemic Stroke #MMPMID25977681 Zhao J; Zhang X; Dong L; Wen Y; Cui L Curr Neuropharmacol 2014[Dec]; 12 (6): 564-74 PMID25977681show ga Stroke is the third leading cause of human death. Endothelial dysfunction, thrombogenesis, inflammatory and oxidative stress damage, and angiogenesis play an important role in cerebral ischemic pathogenesis and represent a target for prevention and treatment. Statins have been found to improve endothelial function, modulate thrombogenesis, attenuate inflammatory and oxidative stress damage, and facilitate angiogenesis far beyond lowering cholesterol levels. Statins have also been proved to significantly decrease cardiovascular risk and to improve clinical outcome. Could statins be the new candidate agent for the prevention and therapy in ischemic stroke? In recent years, a vast expansion in the understanding of the pathophysiology of ischemic stroke and the pleiotropic effects of statins has occurred and clinical trials involving statins for the prevention and treatment of ischemic stroke have begun. These facts force us to revisit ischemic stroke and consider new strategies for prevention and treatment. Here, we survey the important developments in the non-lipid dependent pleiotropic effects and clinical effects of statins in ischemic stroke. äThe Many Roles of Statins in Ischemic Stroke (epmc).pdf DeepDyve Pubget Overpricing