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10.1016/j.molcel.2015.03.020 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.03.020 C4427528!4427528!25891078     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25891078&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 58 (3): 507-21 Nephropedia Template TP {{tp|p=25891078|t=2015. IRGM governs the core autophagy machinery to conduct antimicrobial defense |pdf=|usr=}}{{25891078}} gab.com Text IRGM governs the core autophagy machinery to conduct antimicrobial defense JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25891078 #FOAvip IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through a hitherto unknown mechanism. Here we show how IRGM controls autophagy. IRGM interacts with ULK1 and Beclin 1 and promotes their co-assembly thus governing the formation of autophagy initiation complexes. We further show that IRGM interacts with pattern recognition receptors including NOD2. IRGM, NOD2 and ATG16L1, all of which are Crohn?s disease risk factors, form a molecular complex to modulate autophagic responses to microbial products. NOD2 enhances K63-linked polyubiquitination of IRGM, which is required for interactions of IRGM with the core autophagy factors and for microbial clearance. Thus, IRGM plays a direct role in organizing the core autophagy machinery to endow it with antimicrobial and anti-inflammatory functions. Twit Text FOAVip IRGM governs the core autophagy machinery to conduct antimicrobial defense ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25891078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25891078 #FOAvip English Wikipedia <ref>{{Cite pmid|25891078}}</ref> IRGM governs the core autophagy machinery to conduct antimicrobial defense #MMPMID25891078 Chauhan S; Mandell MA; Deretic V Mol Cell 2015[May]; 58 (3): 507-21 PMID25891078show ga IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through a hitherto unknown mechanism. Here we show how IRGM controls autophagy. IRGM interacts with ULK1 and Beclin 1 and promotes their co-assembly thus governing the formation of autophagy initiation complexes. We further show that IRGM interacts with pattern recognition receptors including NOD2. IRGM, NOD2 and ATG16L1, all of which are Crohn?s disease risk factors, form a molecular complex to modulate autophagic responses to microbial products. NOD2 enhances K63-linked polyubiquitination of IRGM, which is required for interactions of IRGM with the core autophagy factors and for microbial clearance. Thus, IRGM plays a direct role in organizing the core autophagy machinery to endow it with antimicrobial and anti-inflammatory functions. äIRGM governs the core autophagy machinery to conduct antimicrobial def(epmc).pdf DeepDyve Pubget Overpricing