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10.1016/j.molcel.2015.02.028 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.02.028 C4427524!4427524!25818646     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 58 (3): 440-52 Nephropedia Template TP {{tp|p=25818646|t=2015. Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC |pdf=|usr=}}{{25818646}} gab.com Text Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25818646 #FOAvip MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC with its obligate partner, MAX. Here, we show that broad association of MYC with chromatin also depends on interaction with the WD40-repeat protein WDR5. MYC binds WDR5 via an evolutionarily conserved ?MYC box IIIb? motif that engages a shallow, hydrophobic, cleft on the surface of WDR5. Structure-guided mutations in MYC that disrupt interaction with WDR5 attenuate binding of MYC to ~80% of its chromosomal locations and disable its ability to promote induced pluripotent stem cell formation and drive tumorigenesis. Our data reveal WDR5 as a key determinant for MYC recruitment to chromatin and uncover a tractable target for the discovery of anti-cancer therapies against MYC-driven tumors. Twit Text FOAVip Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25818646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25818646 #FOAvip English Wikipedia <ref>{{Cite pmid|25818646}}</ref> Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC #MMPMID25818646 Thomas LR; Wang Q; Grieb BC; Phan J; Foshage AM; Sun Q; Olejniczak ET; Clark T; Dey S; Lorey S; Alicie B; Howard GC; Cawthon B; Ess KC; Eischen CM; Zhao Z; Fesik SW; Tansey WP Mol Cell 2015[May]; 58 (3): 440-52 PMID25818646show ga MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC with its obligate partner, MAX. Here, we show that broad association of MYC with chromatin also depends on interaction with the WD40-repeat protein WDR5. MYC binds WDR5 via an evolutionarily conserved ?MYC box IIIb? motif that engages a shallow, hydrophobic, cleft on the surface of WDR5. Structure-guided mutations in MYC that disrupt interaction with WDR5 attenuate binding of MYC to ~80% of its chromosomal locations and disable its ability to promote induced pluripotent stem cell formation and drive tumorigenesis. Our data reveal WDR5 as a key determinant for MYC recruitment to chromatin and uncover a tractable target for the discovery of anti-cancer therapies against MYC-driven tumors. äInteraction with WDR5 Promotes Target Gene Recognition and Tumorigenes(epmc).pdf DeepDyve Pubget Overpricing