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10.1016/j.cell.2015.03.031 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.03.031 C4426972!4426972!25957682     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (4): 737-49 Nephropedia Template TP {{tp|p=25957682|t=2015. Quantifying memory CD8 T cells reveals regionalization of immunosurveillance |pdf=|usr=}}{{25957682}} gab.com Text Quantifying memory CD8 T cells reveals regionalization of immunosurveillance JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25957682 #FOAvip Memory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces, thus infection detection rates depend on memory cell number and distribution. Population analyses rely on isolation from whole organs and interpretation is predicated on presumptions of near complete cell recovery. Paradigmatically, memory is parsed into central, effector, and resident subsets, ostensibly defined by immunosurveillance patterns, but in practice identified by phenotypic markers. Because isolation methods ultimately inform models of memory T cell differentiation, protection, and vaccine translation, we tested their validity via parabiosis and quantitative immunofluorescence microscopy of a mouse memory CD8 T cell population. We report three major findings: lymphocyte isolation fails to recover most cells and biases against certain subsets, residents greatly outnumber recirculating cells within nonlymphoid tissues, and memory subset homing to inflammation does not conform to previously hypothesized migration patterns. These results indicate that most host cells are surveyed for reinfection by segregated residents rather than by recirculating cells that migrate throughout the blood and body. Twit Text FOAVip Quantifying memory CD8 T cells reveals regionalization of immunosurveillance ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25957682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25957682 #FOAvip English Wikipedia <ref>{{Cite pmid|25957682}}</ref> Quantifying memory CD8 T cells reveals regionalization of immunosurveillance #MMPMID25957682 Steinert EM; Schenkel JM; Fraser KA; Beura LK; Manlove LS; Igyártó BZ; Southern PJ; Masopust D Cell 2015[May]; 161 (4): 737-49 PMID25957682show ga Memory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces, thus infection detection rates depend on memory cell number and distribution. Population analyses rely on isolation from whole organs and interpretation is predicated on presumptions of near complete cell recovery. Paradigmatically, memory is parsed into central, effector, and resident subsets, ostensibly defined by immunosurveillance patterns, but in practice identified by phenotypic markers. Because isolation methods ultimately inform models of memory T cell differentiation, protection, and vaccine translation, we tested their validity via parabiosis and quantitative immunofluorescence microscopy of a mouse memory CD8 T cell population. We report three major findings: lymphocyte isolation fails to recover most cells and biases against certain subsets, residents greatly outnumber recirculating cells within nonlymphoid tissues, and memory subset homing to inflammation does not conform to previously hypothesized migration patterns. These results indicate that most host cells are surveyed for reinfection by segregated residents rather than by recirculating cells that migrate throughout the blood and body. äQuantifying memory CD8 T cells reveals regionalization of immunosurvei(epmc).pdf DeepDyve Pubget Overpricing