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10.1073/pnas.1502111112

http://scihub22266oqcxt.onion/10.1073/pnas.1502111112
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C4426403!4426403!25901323
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suck abstract from ncbi


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pmid25901323      Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (18): 5720-5
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  • Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell #MMPMID25901323
  • Neelam S; Chancellor TJ; Li Y; Nickerson JA; Roux KJ; Dickinson RB; Lele TP
  • Proc Natl Acad Sci U S A 2015[May]; 112 (18): 5720-5 PMID25901323show ga
  • In a cell that is not actively moving, the shape of the nucleus and its central position are robustly maintained in a mechanical homeostasis. How nuclear shape and position are maintained despite the various types of intracellular forces that act on the nuclear surface is an open question. Dysregulated positioning and irregular nuclear shape are associated with a variety of human pathologies. In this paper we estimate the magnitude of the forces that are required to displace and deform the cell nucleus and identify the main molecules that resist these forces. Our results are important because they reveal how the nucleus has such a stable shape and position in the cell, despite the different forces acting on it.
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