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10.1101/cshperspect.a019620

http://scihub22266oqcxt.onion/10.1101/cshperspect.a019620
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C4426252!4426252!25384766
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suck abstract from ncbi

pmid25384766      Cold+Spring+Harb+Perspect+Med 2015 ; 5 (6): ä
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  • Innate Defense against Fungal Pathogens #MMPMID25384766
  • Drummond RA; Gaffen SL; Hise AG; Brown GD
  • Cold Spring Harb Perspect Med 2015[Jun]; 5 (6): ä PMID25384766show ga
  • Human fungal infections have been on the rise in recent years and proved increasingly difficult to treat as a result of the lack of diagnostics, effective antifungal therapies, and vaccines. Most pathogenic fungi do not cause disease unless there is a disturbance in immune homeostasis, which can be caused by modern medical interventions, disease-induced immunosuppression, and naturally occurring human mutations. The innate immune system is well equipped to recognize and destroy pathogenic fungi through specialized cells expressing a broad range of pattern recognition receptors (PRRs). This review will outline the cells and PRRs required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17 and recently characterized antifungal inflammasomes.
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