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Transgelin: a potentially useful diagnostic marker differentially expressed in
triple-negative and non-triple-negative breast cancers
#MMPMID25841305
Rao D
; Kimler BF
; Nothnick WB
; Davis MK
; Fan F
; Tawfik O
Hum Pathol
2015[Jun]; 46
(6
): 876-83
PMID25841305
show ga
Triple negative (TN) (estrogen receptor [ER], progesterone receptor [PR] and
HER2-) are highly aggressive, rapidly growing, hormone-unresponsive tumors
diagnosed at later stage that affect younger women with shorter overall survival.
Most TN tumors are of the basal type. For the remainder, identification of target
markers for effective treatment strategies remains a challenge. Transgelin (TGLN)
is a 22-kd actin-binding protein of the calponin family. It is one of the
earliest markers of smooth muscle differentiation. TGLN has been shown to have
important biologic activities including regulating muscle fiber contractility,
cell migration, and tumor suppression. We examined TGLN expression in the
different molecular subtypes of breast cancer. TGLN expression was examined as a
function of tumor size, grade, histologic type, lymph node status, patients' age
and overall survival, ER, PR, HER2, and Ki-67 in 101 tumors that included 35
luminal A, 28 luminal B, 4 HER2, and 34 TN types. TGLN positivity (defined as 2+
or 3+) was associated with more aggressive tumors (10% of grade I/II tumors were
TGLN+ versus 53% of grade III tumors; P < .001), high Ki-67 count, and low ER and
PR expression (P < .001) but not with tumor size, age, or lymph node metastasis.
TN (n = 34) tumors were 7.7 times more likely to be TGLN+ than non-TN (n = 67)
tumors (77% versus 10%, respectively; P < .001). TGLN may be an excellent
diagnostic marker of TN tumors and could be useful in stratification of patients.
TGLN may also prove a potential target for future treatment strategies.
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