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10.1002/eji.201344398 http://scihub22266oqcxt.onion/10.1002/eji.201344398 C4426035!4426035!25808452     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2015 ; 45 (5): 1287-95 Nephropedia Template TP {{tp|p=25808452|t=2015. Seeing through the dark: New insights into the immune regulatory functions of vitamin A |pdf=|usr=}}{{25808452}} gab.com Text Seeing through the dark: New insights into the immune regulatory functions of vitamin A JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25808452 #FOAvip The importance of vitamin A for host defense is undeniable and the study of its mechanisms is paramount. Of the estimated 250 million preschool children who are vitamin A deficient (VAD), 10% will die from their increased susceptibility to infectious disease. Vitamin A supplementation was established in the 1980s as one of the most successful interventions in the developing world. Understanding how Vitamin A controls immunity will curb the mortality and morbidity associated with VAD and exploit the immune enhancing capacity of vitamin A to heighten host resistance to infectious disease. The discoveries that retinoic acid (RA) imprints the homing of leukocytes to the gut and enhanced the induction of regulatory T-cells highlighted a potential role for RA in mucosal tolerance. However, emerging data tells of a more profound systemic impact of RA on leukocyte function and commitment. In animal models using genetic manipulation of RA signaling, we learn when and how RA controls T-cell fate. Here we review the role for RA as a critical checkpoint regulator in the differentiation of CD4+ T-cells within the immune system. Twit Text FOAVip Seeing through the dark: New insights into the immune regulatory functions of vitamin A ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25808452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25808452 #FOAvip English Wikipedia <ref>{{Cite pmid|25808452}}</ref> Seeing through the dark: New insights into the immune regulatory functions of vitamin A #MMPMID25808452 Brown CC; Noelle RJ Eur J Immunol 2015[May]; 45 (5): 1287-95 PMID25808452show ga The importance of vitamin A for host defense is undeniable and the study of its mechanisms is paramount. Of the estimated 250 million preschool children who are vitamin A deficient (VAD), 10% will die from their increased susceptibility to infectious disease. Vitamin A supplementation was established in the 1980s as one of the most successful interventions in the developing world. Understanding how Vitamin A controls immunity will curb the mortality and morbidity associated with VAD and exploit the immune enhancing capacity of vitamin A to heighten host resistance to infectious disease. The discoveries that retinoic acid (RA) imprints the homing of leukocytes to the gut and enhanced the induction of regulatory T-cells highlighted a potential role for RA in mucosal tolerance. However, emerging data tells of a more profound systemic impact of RA on leukocyte function and commitment. In animal models using genetic manipulation of RA signaling, we learn when and how RA controls T-cell fate. Here we review the role for RA as a critical checkpoint regulator in the differentiation of CD4+ T-cells within the immune system. äSeeing through the dark: New insights into the immune regulatory funct(epmc).pdf DeepDyve Pubget Overpricing