Sphingolipids in the DNA Damage Response #MMPMID25434743
Carroll B; Donaldson C; Obeid L
Adv Biol Regul 2015[May]; 58 (ä): 38-52 PMID25434743show ga
Recently, sphingolipid metabolizing enzymes have emerged as important targets of many chemotherapeutics and DNA damaging agents and therefore play significant roles in mediating the physiological response of the cell to DNA damage. In this review we will highlight points of connection between the DNA damage response (DDR) and sphingolipid metabolism; specifically how certain sphingolipid enzymes are regulated in response to DNA damage and how the bioactive lipids produced by these enzymes affect cell fate.