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10.1093/infdis/jiu612 http://scihub22266oqcxt.onion/10.1093/infdis/jiu612 C4425823!4425823!25398459     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25398459&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2015 ; 211 (10): 1658-76 Nephropedia Template TP {{tp|p=25398459|t=2015. Transcriptional Changes That Characterize the Immune Reactions of Leprosy |pdf=|usr=}}{{25398459}} gab.com Text Transcriptional Changes That Characterize the Immune Reactions of Leprosy JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25398459 #FOAvip Background.?Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).Methods.?To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry.Results.?There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the ?complement and coagulation? pathway common to both. Interferon ? was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL.Conclusions.?These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis. Twit Text FOAVip Transcriptional Changes That Characterize the Immune Reactions of Leprosy ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25398459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25398459 #FOAvip English Wikipedia <ref>{{Cite pmid|25398459}}</ref> Transcriptional Changes That Characterize the Immune Reactions of Leprosy #MMPMID25398459 Dupnik KM; Bair TB; Maia AO; Amorim FM; Costa MR; Keesen TSL; Valverde JG; Queiroz Mdo CAP; Medeiros LL; de Lucena NL; Wilson ME; Nobre ML; Johnson WD; Jeronimo SMB J Infect Dis 2015[May]; 211 (10): 1658-76 PMID25398459show ga Background.?Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).Methods.?To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry.Results.?There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the ?complement and coagulation? pathway common to both. Interferon ? was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL.Conclusions.?These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis. äTranscriptional Changes That Characterize the Immune Reactions of Lepr(epmc).pdf DeepDyve Pubget Overpricing