Molecular phenotyping of T cell-mediated rejection #MMPMID25347945
Chong AS; Perkins DL
Nat Rev Nephrol 2014[Dec]; 10 (12): 678-80 PMID25347945show ga
A new study has reported a molecular signature of T cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-? and macrophages. Inhibitors of T cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.