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10.1126/scitranslmed.3010302 http://scihub22266oqcxt.onion/10.1126/scitranslmed.3010302 C4425193!4425193 !25787765     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25787765 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells |pdf=|usr=}}{{25787765 }} gab.com Text Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25787765 #FOAvip The skin of an adult human contains about 20 billion memory T cells. Epithelial barrier tissues are infiltrated by a combination of resident and recirculating T cells in mice, but the relative proportions and functional activities of resident versus recirculating T cells have not been evaluated in human skin. We discriminated resident from recirculating T cells in human-engrafted mice and lymphoma patients using alemtuzumab, a medication that depletes recirculating T cells from skin, and then analyzed these T cell populations in healthy human skin. All nonrecirculating resident memory T cells (TRM) expressed CD69, but most were CD4(+), CD103(-), and located in the dermis, in contrast to studies in mice. Both CD4(+) and CD8(+) CD103(+) TRM were enriched in the epidermis, had potent effector functions, and had a limited proliferative capacity compared to CD103(-) TRM. TRM of both types had more potent effector functions than recirculating T cells. We observed two distinct populations of recirculating T cells, CCR7(+)/L-selectin(+) central memory T cells (TCM) and CCR7(+)/L-selectin(-) T cells, which we term migratory memory T cells (TMM). Circulating skin-tropic TMM were intermediate in cytokine production between TCM and effector memory T cells. In patients with cutaneous T cell lymphoma, malignant TCM and TMM induced distinct inflammatory skin lesions, and TMM were depleted more slowly from skin after alemtuzumab, suggesting that TMM may recirculate more slowly. In summary, human skin is protected by four functionally distinct populations of T cells, two resident and two recirculating, with differing territories of migration and distinct functional activities. Twit Text FOAVip Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=25787765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25787765 #FOAvip English Wikipedia <ref>{{Cite pmid|25787765 }}</ref> Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells #MMPMID25787765 Watanabe R ; Gehad A ; Yang C ; Scott LL ; Teague JE ; Schlapbach C ; Elco CP ; Huang V ; Matos TR ; Kupper TS ; Clark RA Sci Transl Med 2015[Mar]; 7 (279 ): 279ra39 PMID25787765 show ga The skin of an adult human contains about 20 billion memory T cells. Epithelial barrier tissues are infiltrated by a combination of resident and recirculating T cells in mice, but the relative proportions and functional activities of resident versus recirculating T cells have not been evaluated in human skin. We discriminated resident from recirculating T cells in human-engrafted mice and lymphoma patients using alemtuzumab, a medication that depletes recirculating T cells from skin, and then analyzed these T cell populations in healthy human skin. All nonrecirculating resident memory T cells (TRM) expressed CD69, but most were CD4(+), CD103(-), and located in the dermis, in contrast to studies in mice. Both CD4(+) and CD8(+) CD103(+) TRM were enriched in the epidermis, had potent effector functions, and had a limited proliferative capacity compared to CD103(-) TRM. TRM of both types had more potent effector functions than recirculating T cells. We observed two distinct populations of recirculating T cells, CCR7(+)/L-selectin(+) central memory T cells (TCM) and CCR7(+)/L-selectin(-) T cells, which we term migratory memory T cells (TMM). Circulating skin-tropic TMM were intermediate in cytokine production between TCM and effector memory T cells. In patients with cutaneous T cell lymphoma, malignant TCM and TMM induced distinct inflammatory skin lesions, and TMM were depleted more slowly from skin after alemtuzumab, suggesting that TMM may recirculate more slowly. In summary, human skin is protected by four functionally distinct populations of T cells, two resident and two recirculating, with differing territories of migration and distinct functional activities. |Alemtuzumab [MESH] |Animals [MESH] |Antibodies, Monoclonal, Humanized/*therapeutic use [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, T-Lymphocyte/metabolism [MESH] |CD4-Positive T-Lymphocytes/cytology [MESH] |CD8-Positive T-Lymphocytes/cytology [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Integrin alpha Chains/metabolism [MESH] |Interleukin-2/metabolism [MESH] |Keratinocytes/cytology [MESH] |Lectins, C-Type/metabolism [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Phenotype [MESH] |Skin/*immunology/*metabolism [MESH]Human skin is protected by four functionally and phenotypically discre(epmc).pdf DeepDyve Pubget Overpricing