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10.1126/scitranslmed.3010641

http://scihub22266oqcxt.onion/10.1126/scitranslmed.3010641
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C4425129!4425129!25568072
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suck abstract from ncbi

pmid25568072      Sci+Transl+Med 2015 ; 7 (269): 269rv1
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  • Resident memory T cells in human health and disease #MMPMID25568072
  • Clark RA
  • Sci Transl Med 2015[Jan]; 7 (269): 269rv1 PMID25568072show ga
  • Resident memory T cells are non-recirculating memory T cells that persist long term in epithelial barrier tissues, including the gastrointestinal tract, lung, skin and reproductive tract. Resident memory T cells persist in the absence of antigens, have impressive effector functions and provide rapid on-site immune protection against known pathogens in peripheral tissues. A fundamentally distinct gene expression program differentiates resident memory T cells from circulating T cells. Although these cells likely evolved to provide rapid immune protection against pathogens, autoreactive, aberrantly activated and malignant resident memory cells contribute to numerous human inflammatory diseases including mycosis fungoides and psoriasis. This review will discuss both the science and medicine of resident memory T cells, exploring how these cells contribute to healthy immune function and discussing what is known about how these cells contribute to human inflammatory and autoimmune diseases.
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