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10.1074/jbc.M115.649301

http://scihub22266oqcxt.onion/10.1074/jbc.M115.649301
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C4424351!4424351!25792739
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suck abstract from ncbi


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pmid25792739      J+Biol+Chem 2015 ; 290 (19): 12184-94
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  • UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)* #MMPMID25792739
  • Kemp MG; Lindsey-Boltz LA; Sancar A
  • J Biol Chem 2015[May]; 290 (19): 12184-94 PMID25792739show ga
  • Background: UV wavelengths of sunlight exacerbate the symptoms of autoimmunity.Results: UV and UV-mimetic chemical carcinogens stimulate STING-dependent innate immune signaling in keratinocytes and other human cells by disrupting the STING negative regulator ULK1.Conclusion: STING-dependent innate immune signaling is elevated in UV-irradiated human cells.Significance: Deregulation of innate immune signaling by UV light may contribute to autoimmunity.
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