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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Head+Neck+Pathol
2015 ; 9
(2
): 205-13
Nephropedia Template TP
gab.com Text
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Basal cell adenocarcinoma and Basal cell adenoma of the salivary glands: a
clinicopathological review of seventy tumors with comparison of morphologic
features and growth control indices
#MMPMID25141971
Wilson TC
; Robinson RA
Head Neck Pathol
2015[Jun]; 9
(2
): 205-13
PMID25141971
show ga
Basal cell adenoma and basal cell adenocarcinoma represent uncommon basaloid
salivary gland neoplasms that show marked morphologic similarity. We wished to
compare clinical outcome and morphologic features as well as growth and
proliferation associated markers for both neoplasms. We reviewed the pathologic
features of 70 neoplasms diagnosed as basal cell adenoma or basal cell
adenocarcinoma. Observations included maximum mitotic activity and presence or
absence of invasion into surrounding normal tissues as well as
immunohistochemical studies for Ki-67, caspase 3, p53, and bcl-2. Establishing
malignancy on the basis of invasion into surrounding benign tissues, 41 basal
cell adenomas and 29 basal cell adenocarcinomas were identified. For tumors with
follow-up, recurrence rates were 6.7 % for basal cell adenoma and 16.7 % for
basal cell adenocarcinoma. One patient with basal cell adenocarcinoma had distant
metastases and died of disease. Overall basal cell adenocarcinomas showed
significantly higher values for growth and proliferation markers compared to
basal cell adenomas. Salivary gland basal cell adenoma and basal cell
adenocarcinoma show morphologic similarity. Basal cell adenocarcinoma can exhibit
a locally aggressive behavior and has potential metastatic behavior. The overall
mitotic rate and Ki-67 expression were higher in basal cell adenocarcinoma
compared to basal cell adenoma, but overlap between the results of these
observations in each tumor did not allow for accurate diagnosis or prediction of
outcome in individual cases. We conclude that morphologic observation of local
tissue invasion is the best marker for separating basal cell adenoma from basal
cell adenocarcinoma.