Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25141970
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Head+Neck+Pathol
2015 ; 9
(2
): 181-95
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67
cases with a review of the literature
#MMPMID25141970
Thompson LD
; Bauer JL
; Chiosea S
; McHugh JB
; Seethala RR
; Miettinen M
; Müller S
Head Neck Pathol
2015[Jun]; 9
(2
): 181-95
PMID25141970
show ga
There is a lack of a comprehensive immunohistochemical (IHC) analysis of
canalicular adenoma (CanAd), especially when combined with a description of the
unique histologic features. Given the usual small biopsies, IHC may be useful in
distinguishing CanAd from other tumors in the differential diagnosis.
Retrospective. The patients included 54 females and 13 males (4.2:1), aged
43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation
was generally a mass (n = 61) slowly increasing in size (mean 38.5 months),
affecting the upper lip (n = 46), buccal mucosa (n = 17) or palate (n = 4),
involving the right (n = 29), left (n = 24) or midline (n = 9), without any major
salivary gland tumors. The tumors ranged in size from 0.2 to 3 cm (mean 1.2 cm).
Most tumors were multilobular or bosselated (76 %), often surrounded by a
capsule. Histologically, the tumors were characterized by cystic spaces, tumor
cords with beading, tubule formation, and by the presence of luminal squamous
balls (n = 41). The cells were cuboidal to columnar with stippled chromatin.
Mitoses were inconspicuous. A myxoid stroma (n = 64), sclerosis (n = 42), luminal
hemorrhage (n = 51), and luminal microliths (calcifications) (n = 33) were
characteristic. Nine (13.4 %) were multifocal. CanAd showed the following
characteristic immunohistochemistry findings: CK-pan and S100 protein (strong,
diffuse reaction); peripheral or luminal GFAP reaction; CK5/6 and p16 luminal
squamous ball reaction; SOX10 nuclear reaction; cytoplasmic p63 reaction. CanAd
are unique minor salivary gland tumors showing a distinct architecture and
phenotype. They predilect to older women, with the majority multilobulated and
affecting the upper lip, multifocal in 13 %; no major salivary gland tumors were
identified. S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal
squamous balls highlighted by CK5/6 or p16.