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10.1016/j.imbio.2014.12.011 http://scihub22266oqcxt.onion/10.1016/j.imbio.2014.12.011 C4424133!4424133!25641411     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25641411&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunobiology 2015 ; 220 (6): 823-32 Nephropedia Template TP {{tp|p=25641411|t=2015. Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes |pdf=|usr=}}{{25641411}} gab.com Text Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=25641411 #FOAvip Scavenger Receptor Associated with Endothelial Cells (SREC-I) was previously shown to be expressed by immune cells and to play a role in CD8+-mediated T cell immunity. SREC-I was also shown to modulate the function of Toll like receptors with essential roles in innate immunity. Here we have shown that SREC-I enhanced double stranded RNA (dsRNA)-mediated Toll like receptor-3 (TLR3) activation. Viral double stranded RNA (dsRNA) was demonstrated to be a pathogen associated molecular pattern (PAMP) signaling viral infection. We found that in human monocyte/macrophage THP1 cells as well as murine bone marrow derived macrophages SREC-I led to elevated responses to the dsRNA-like molecule polyinosine-polycytidylic acid (Poly I:C) and enhanced production of inflammatory cytokines. Our data also showed that intracellular/endocytic TLR3 could directly interact with SREC-I in the presence of Poly I: C. The internalized ligand, along with TLR3 and SREC-I localized in endosomes within macrophages and in HEK293 cells engineered to express TLR3 and SREC-I. SREC-I also stimulated dsRNA-mediated TLR3 activation of signaling through the NF??, MAP kinase and interferon regulatory factor 3 (IRF3) pathways leading to expression of cytokines, most notably interleukin-8 and interferon-?. We therefore hypothesized that SREC-I could be a receptor capable of internalizing Poly I: C, boosting TLR3 mediated inflammatory signaling and stimulating cytokine production in macrophages. Twit Text FOAVip Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=25641411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25641411 #FOAvip English Wikipedia <ref>{{Cite pmid|25641411}}</ref> Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes #MMPMID25641411 Murshid A; Gong J; Ahmad R; Borges TJ; Calderwood SK Immunobiology 2015[Jun]; 220 (6): 823-32 PMID25641411show ga Scavenger Receptor Associated with Endothelial Cells (SREC-I) was previously shown to be expressed by immune cells and to play a role in CD8+-mediated T cell immunity. SREC-I was also shown to modulate the function of Toll like receptors with essential roles in innate immunity. Here we have shown that SREC-I enhanced double stranded RNA (dsRNA)-mediated Toll like receptor-3 (TLR3) activation. Viral double stranded RNA (dsRNA) was demonstrated to be a pathogen associated molecular pattern (PAMP) signaling viral infection. We found that in human monocyte/macrophage THP1 cells as well as murine bone marrow derived macrophages SREC-I led to elevated responses to the dsRNA-like molecule polyinosine-polycytidylic acid (Poly I:C) and enhanced production of inflammatory cytokines. Our data also showed that intracellular/endocytic TLR3 could directly interact with SREC-I in the presence of Poly I: C. The internalized ligand, along with TLR3 and SREC-I localized in endosomes within macrophages and in HEK293 cells engineered to express TLR3 and SREC-I. SREC-I also stimulated dsRNA-mediated TLR3 activation of signaling through the NF??, MAP kinase and interferon regulatory factor 3 (IRF3) pathways leading to expression of cytokines, most notably interleukin-8 and interferon-?. We therefore hypothesized that SREC-I could be a receptor capable of internalizing Poly I: C, boosting TLR3 mediated inflammatory signaling and stimulating cytokine production in macrophages. äScavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 a(epmc).pdf DeepDyve Pubget Overpricing