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2015 ; 479-480
(ä): 234-46
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Transmission of influenza A viruses
#MMPMID25812763
Neumann G
; Kawaoka Y
Virology
2015[May]; 479-480
(ä): 234-46
PMID25812763
show ga
Influenza A viruses cause respiratory infections that range from asymptomatic to
deadly in humans. Widespread outbreaks (pandemics) are attributable to 'novel'
viruses that possess a viral hemagglutinin (HA) gene to which humans lack
immunity. After a pandemic, these novel viruses form stable virus lineages in
humans and circulate until they are replaced by other novel viruses. The factors
and mechanisms that facilitate virus transmission among hosts and the
establishment of novel lineages are not completely understood, but the HA and
basic polymerase 2 (PB2) proteins are thought to play essential roles in these
processes by enabling avian influenza viruses to infect mammals and replicate
efficiently in their new host. Here, we summarize our current knowledge of the
contributions of HA, PB2, and other viral components to virus transmission and
the formation of new virus lineages.