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10.1016/j.virol.2014.12.033 http://scihub22266oqcxt.onion/10.1016/j.virol.2014.12.033 C4424083!4424083!25620767     free     free     free       Virology 2015 ; ä (ä): 180-93 Nephropedia Template TP {{tp|p=25620767|t=2015. T Cell Exhaustion During Persistent Viral Infections |pdf=|usr=}}{{25620767}} gab.com Text T Cell Exhaustion During Persistent Viral Infections JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the development of functionally inferior, exhausted, T cell responses. Exhaustion develops in a step-wise and progressive manner, ranges in severity, and can culminate in the deletion of the anti-viral T cells. This disarming of the response is consequential as it compromises viral control and potentially serves to dampen immune-mediated damage. Exhausted T cells are unable to elaborate typical anti-viral effector functions. They are characterized by the sustained upregulation of inhibitory receptors and display a gene expression profile that distinguishes them from prototypic effector and memory T cell populations. In this review we discuss the properties of exhausted T cells; the virological and immunological conditions that favor their development; the cellular and molecular signals that sustain the exhausted state; and strategies for preventing and reversing exhaustion to favor viral control. Twit Text FOAVip T Cell Exhaustion During Persistent Viral Infections ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip English Wikipedia <ref>{{Cite pmid|25620767}}</ref> T Cell Exhaustion During Persistent Viral Infections #MMPMID25620767 Kahan SM; Wherry EJ; Zajac AJ Virology 2015[May]; ä (ä): 180-93 PMID25620767show ga Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the development of functionally inferior, exhausted, T cell responses. Exhaustion develops in a step-wise and progressive manner, ranges in severity, and can culminate in the deletion of the anti-viral T cells. This disarming of the response is consequential as it compromises viral control and potentially serves to dampen immune-mediated damage. Exhausted T cells are unable to elaborate typical anti-viral effector functions. They are characterized by the sustained upregulation of inhibitory receptors and display a gene expression profile that distinguishes them from prototypic effector and memory T cell populations. In this review we discuss the properties of exhausted T cells; the virological and immunological conditions that favor their development; the cellular and molecular signals that sustain the exhausted state; and strategies for preventing and reversing exhaustion to favor viral control. äT Cell Exhaustion During Persistent Viral Infections (epmc).pdf DeepDyve Pubget Overpricing