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10.1016/j.molmed.2015.02.004 http://scihub22266oqcxt.onion/10.1016/j.molmed.2015.02.004 C4424065!4424065!25801125     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Mol+Med 2015 ; 21 (5): 319-29 Nephropedia Template TP {{tp|p=25801125|t=2015. The Perfect Storm: HLA Antibodies, Complement, Fc?Rs and Endothelium in Transplant Rejection |pdf=|usr=}}{{25801125}} gab.com Text The Perfect Storm: HLA Antibodies, Complement, Fc Rs and Endothelium in Transplant Rejection JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25801125 #FOAvip The pathophysiology of antibody-mediated rejection (AMR) in solid organ transplants is multi-faceted and predominantly caused by antibodies directed against polymorphic donor human leukocyte antigens (HLA). Despite the clearly detrimental impact of HLA antibodies (HLA-Ab) on graft function and survival, the prevention, diagnosis and treatment of AMR remain a challenge. Histological manifestations of AMR reflect signatures of HLA-Ab-triggered injury, specifically endothelial changes, recipient leukocytic infiltrate, and complement deposition. We review the interconnected mechanisms of HLA-Ab-mediated injury that might synergize in a ?perfect storm? of inflammation. Characterization of antibody features that are critical for effector functions may help identify HLA-Ab more likely to cause rejection. We also highlight recent advancements that may pave the way for new, more effective therapeutics. Twit Text FOAVip The Perfect Storm: HLA Antibodies, Complement, Fc Rs and Endothelium in Transplant Rejection ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25801125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25801125 #FOAvip English Wikipedia <ref>{{Cite pmid|25801125}}</ref> The Perfect Storm: HLA Antibodies, Complement, Fc?Rs and Endothelium in Transplant Rejection #MMPMID25801125 Thomas KA; Valenzuela NM; Reed EF Trends Mol Med 2015[May]; 21 (5): 319-29 PMID25801125show ga The pathophysiology of antibody-mediated rejection (AMR) in solid organ transplants is multi-faceted and predominantly caused by antibodies directed against polymorphic donor human leukocyte antigens (HLA). Despite the clearly detrimental impact of HLA antibodies (HLA-Ab) on graft function and survival, the prevention, diagnosis and treatment of AMR remain a challenge. Histological manifestations of AMR reflect signatures of HLA-Ab-triggered injury, specifically endothelial changes, recipient leukocytic infiltrate, and complement deposition. We review the interconnected mechanisms of HLA-Ab-mediated injury that might synergize in a ?perfect storm? of inflammation. Characterization of antibody features that are critical for effector functions may help identify HLA-Ab more likely to cause rejection. We also highlight recent advancements that may pave the way for new, more effective therapeutics. äThe Perfect Storm: HLA Antibodies, Complement, Fc?Rs and Endothelium i(epmc).pdf DeepDyve Pubget Overpricing