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10.1038/cdd.2014.188 http://scihub22266oqcxt.onion/10.1038/cdd.2014.188 C4423183!4423183!25412630     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2015 ; 22 (6): 1000-11 Nephropedia Template TP {{tp|p=25412630|t=2015. Regulation of c-Myc protein stability by proteasome activator REG? |pdf=|usr=}}{{25412630}} gab.com Text Regulation of c-Myc protein stability by proteasome activator REG JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25412630 #FOAvip c-Myc is a key transcriptional factor that has a prominent role in cell growth, differentiation and tumor development. Its protein levels are tightly controlled by ubiquitin-proteasome pathway and frequently deregulated in various cancers. Here, we report that the 11S proteasomal activator REG? is a novel regulator of c-Myc abundance in cells. We showed that overexpression of wild-type REG?, but not inactive mutants including N151Y and G250S, significantly promoted the degradation of c-Myc. Depletion of REG? markedly increased the protein stability of c-Myc. REG? interacts with the C-terminal region of c-Myc and regulates c-Myc protein turnover. Functionally, REG? negatively regulates c-Myc-mediated cell proliferation. Interestingly, depletion of the Drosophila Reg homolog (dReg) in developing wings induced the upregulation of Drosophila Myc, which contributes to cell death. Collectively, these results suggest that REG? proteasome has a conserved role in the regulation of Myc abundance in both mammalian cells and Drosophila. Twit Text FOAVip Regulation of c-Myc protein stability by proteasome activator REG ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25412630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25412630 #FOAvip English Wikipedia <ref>{{Cite pmid|25412630}}</ref> Regulation of c-Myc protein stability by proteasome activator REG? #MMPMID25412630 Li S; Jiang C; Pan J; Wang X; Jin J; Zhao L; Pan W; Liao G; Cai X; Li X; Xiao J; Jiang J; Wang P Cell Death Differ 2015[Jun]; 22 (6): 1000-11 PMID25412630show ga c-Myc is a key transcriptional factor that has a prominent role in cell growth, differentiation and tumor development. Its protein levels are tightly controlled by ubiquitin-proteasome pathway and frequently deregulated in various cancers. Here, we report that the 11S proteasomal activator REG? is a novel regulator of c-Myc abundance in cells. We showed that overexpression of wild-type REG?, but not inactive mutants including N151Y and G250S, significantly promoted the degradation of c-Myc. Depletion of REG? markedly increased the protein stability of c-Myc. REG? interacts with the C-terminal region of c-Myc and regulates c-Myc protein turnover. Functionally, REG? negatively regulates c-Myc-mediated cell proliferation. Interestingly, depletion of the Drosophila Reg homolog (dReg) in developing wings induced the upregulation of Drosophila Myc, which contributes to cell death. Collectively, these results suggest that REG? proteasome has a conserved role in the regulation of Myc abundance in both mammalian cells and Drosophila. äRegulation of c-Myc protein stability by proteasome activator REG? (epmc).pdf DeepDyve Pubget Overpricing