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CD146: the unveiling of a pro-angiogenic netrin receptor #MMPMID25849249
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Cell Res 2015[May]; 25 (5): 533-4 PMID25849249show ga
Netrin-1, a classic neuronal guidance cue, can promote angiogenesis under certain developmental and pathological conditions, but key receptors on vascular endothelium have remained elusive. A recent study published in Cell Research by Tu et al. reveals that CD146, an endothelial receptor of the immunoglobulin superfamily, binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.