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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Physiology+(Bethesda) 2015 ; 30 (3): 195-207 Nephropedia Template TP
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Molecular Pathways and Therapies in Autosomal-Dominant Polycystic Kidney Disease #MMPMID25933820
Saigusa T; Bell PD
Physiology (Bethesda) 2015[May]; 30 (3): 195-207 PMID25933820show ga
Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.