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10.1152/physiol.00032.2014

http://scihub22266oqcxt.onion/10.1152/physiol.00032.2014
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C4422974!4422974!25933820
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suck abstract from ncbi


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pmid25933820      Physiology+(Bethesda) 2015 ; 30 (3): 195-207
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  • Molecular Pathways and Therapies in Autosomal-Dominant Polycystic Kidney Disease #MMPMID25933820
  • Saigusa T; Bell PD
  • Physiology (Bethesda) 2015[May]; 30 (3): 195-207 PMID25933820show ga
  • Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.
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