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10.1016/j.devcel.2015.03.020 http://scihub22266oqcxt.onion/10.1016/j.devcel.2015.03.020 C4421092!4421092!25942623     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2015 ; 33 (3): 314-27 Nephropedia Template TP {{tp|p=25942623|t=2015. DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function |pdf=|usr=}}{{25942623}} gab.com Text DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25942623 #FOAvip Human centromeres are specified by a stably inherited epigenetic mark that maintains centromere position and function through a two-step mechanism relying on self-templating centromeric chromatin assembled with the histone H3 variant CENP-A, followed by CENP-A-dependent nucleation of kinetochore assembly. Nevertheless, natural human centromeres are positioned within specific megabase chromosomal regions containing ?-satellite DNA repeats, which contain binding sites for the DNA sequence specific binding protein CENP-B. We now demonstrate that CENP-B directly binds both CENP-A?s amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly. DNA sequence-dependent binding of CENP-B within ?-satellite repeats is required to stabilize optimal centromeric levels of CENP-C. Chromosomes bearing centromeres without bound CENP-B, including the human Y chromosome, are shown to missegregate in cells at rates several fold higher than chromosomes with CENP-B containing centromeres. These data demonstrate a DNA sequence-specific enhancement by CENP-B of the fidelity of epigenetically defined human centromere function. Twit Text FOAVip DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25942623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25942623 #FOAvip English Wikipedia <ref>{{Cite pmid|25942623}}</ref> DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function #MMPMID25942623 Fachinetti D; Han JS; McMahon MA; Ly P; Abdullah A; Wong AJ; Cleveland DW Dev Cell 2015[May]; 33 (3): 314-27 PMID25942623show ga Human centromeres are specified by a stably inherited epigenetic mark that maintains centromere position and function through a two-step mechanism relying on self-templating centromeric chromatin assembled with the histone H3 variant CENP-A, followed by CENP-A-dependent nucleation of kinetochore assembly. Nevertheless, natural human centromeres are positioned within specific megabase chromosomal regions containing ?-satellite DNA repeats, which contain binding sites for the DNA sequence specific binding protein CENP-B. We now demonstrate that CENP-B directly binds both CENP-A?s amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly. DNA sequence-dependent binding of CENP-B within ?-satellite repeats is required to stabilize optimal centromeric levels of CENP-C. Chromosomes bearing centromeres without bound CENP-B, including the human Y chromosome, are shown to missegregate in cells at rates several fold higher than chromosomes with CENP-B containing centromeres. These data demonstrate a DNA sequence-specific enhancement by CENP-B of the fidelity of epigenetically defined human centromere function. äDNA sequence-specific binding of CENP-B enhances the fidelity of human(epmc).pdf DeepDyve Pubget Overpricing