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10.1128/MCB.01343-14 http://scihub22266oqcxt.onion/10.1128/MCB.01343-14 C4420919!4420919!25802278     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2015 ; 35 (11): 1979-91 Nephropedia Template TP {{tp|p=25802278|t=2015. Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast |pdf=|usr=}}{{25802278}} gab.com Text Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25802278 #FOAvip The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and osteoblast function. In this study, we identify a previously unrecognized skeletal function unique to Lrp5 that enables osteoblasts to oxidize fatty acids. Mice lacking the Lrp5 coreceptor specifically in osteoblasts and osteocytes exhibit the expected reductions in postnatal bone mass but also exhibit an increase in body fat with corresponding reductions in energy expenditure. Conversely, mice expressing a high bone mass mutant Lrp5 allele are leaner with reduced plasma triglyceride and free fatty acid levels. In this context, Wnt-initiated signals downstream of Lrp5, but not the closely related Lrp6 coreceptor, regulate the activation of ?-catenin and thereby induce the expression of key enzymes required for fatty acid ?-oxidation. These results suggest that Wnt-Lrp5 signaling regulates basic cellular activities beyond those associated with fate specification and differentiation in bone and that the skeleton influences global energy homeostasis via mechanisms independent of osteocalcin and glucose metabolism. Twit Text FOAVip Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25802278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25802278 #FOAvip English Wikipedia <ref>{{Cite pmid|25802278}}</ref> Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast #MMPMID25802278 Frey JL; Li Z; Ellis JM; Zhang Q; Farber CR; Aja S; Wolfgang MJ; Clemens TL; Riddle RC Mol Cell Biol 2015[Jun]; 35 (11): 1979-91 PMID25802278show ga The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and osteoblast function. In this study, we identify a previously unrecognized skeletal function unique to Lrp5 that enables osteoblasts to oxidize fatty acids. Mice lacking the Lrp5 coreceptor specifically in osteoblasts and osteocytes exhibit the expected reductions in postnatal bone mass but also exhibit an increase in body fat with corresponding reductions in energy expenditure. Conversely, mice expressing a high bone mass mutant Lrp5 allele are leaner with reduced plasma triglyceride and free fatty acid levels. In this context, Wnt-initiated signals downstream of Lrp5, but not the closely related Lrp6 coreceptor, regulate the activation of ?-catenin and thereby induce the expression of key enzymes required for fatty acid ?-oxidation. These results suggest that Wnt-Lrp5 signaling regulates basic cellular activities beyond those associated with fate specification and differentiation in bone and that the skeleton influences global energy homeostasis via mechanisms independent of osteocalcin and glucose metabolism. äWnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast (epmc).pdf DeepDyve Pubget Overpricing