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10.1016/j.clim.2015.03.001 http://scihub22266oqcxt.onion/10.1016/j.clim.2015.03.001 C4420722!4420722!25769244     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2015 ; 158 (1): 8-18 Nephropedia Template TP {{tp|p=25769244|t=2015. Transforming growth factor-?1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants |pdf=|usr=}}{{25769244}} gab.com Text Transforming growth factor- 1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25769244 #FOAvip Transforming growth factor-?1 (TGF-?1) is an important immunoregulatory cytokine that plays an obligate role in regulating T-cell functions. Here, we demonstrated the role of TGF-?1 in regulating the survival of intestinal epithelial cells (ECs) in rhesus colon explant cultures using either anti-TGF-?1 antibody or recombinant TGF-?1 proteins. Neutralization of endogenous TGF-?1 using anti-TGF-?1 antibodies induced apoptosis of both intestinal ECs and lamina propria (LP) cells. Additionally, endogenous TGF-?1 blocking significantly increased expression of IFN?, TNF?, CD107a and Perforin in LP cells compared to media and isotype controls. A significant decrease in pAKT expression was detected in anti-TGF-?1 MAbs treated explants compared to isotype and rTGF-?1 protein treated explants. Our results demonstrated TGF-?1 regulated pAKT and IFN? expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-?1 in regulating intestinal homeostasis and EC integrity. Twit Text FOAVip Transforming growth factor- 1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25769244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25769244 #FOAvip English Wikipedia <ref>{{Cite pmid|25769244}}</ref> Transforming growth factor-?1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants #MMPMID25769244 Pahar B; Pan D; Lala W; Kenway-Lynch CS; Das A Clin Immunol 2015[May]; 158 (1): 8-18 PMID25769244show ga Transforming growth factor-?1 (TGF-?1) is an important immunoregulatory cytokine that plays an obligate role in regulating T-cell functions. Here, we demonstrated the role of TGF-?1 in regulating the survival of intestinal epithelial cells (ECs) in rhesus colon explant cultures using either anti-TGF-?1 antibody or recombinant TGF-?1 proteins. Neutralization of endogenous TGF-?1 using anti-TGF-?1 antibodies induced apoptosis of both intestinal ECs and lamina propria (LP) cells. Additionally, endogenous TGF-?1 blocking significantly increased expression of IFN?, TNF?, CD107a and Perforin in LP cells compared to media and isotype controls. A significant decrease in pAKT expression was detected in anti-TGF-?1 MAbs treated explants compared to isotype and rTGF-?1 protein treated explants. Our results demonstrated TGF-?1 regulated pAKT and IFN? expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-?1 in regulating intestinal homeostasis and EC integrity. äTransforming growth factor-?1 regulated phosphorylated AKT and interfe(epmc).pdf DeepDyve Pubget Overpricing