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10.1016/j.it.2015.03.004 http://scihub22266oqcxt.onion/10.1016/j.it.2015.03.004 C4420642!4420642!25818864     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2015 ; 36 (5): 300-6 Nephropedia Template TP {{tp|p=25818864|t=2015. Codification of bidentate pMHC interaction with TCR and co-receptor |pdf=|usr=}}{{25818864}} gab.com Text Codification of bidentate pMHC interaction with TCR and co-receptor JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25818864 #FOAvip A 1983 Immunology Today rostrum hypothesized that each T cell has two recognition units: a TCR complex which binds antigen associated with a polymorphic region of an MHC molecule (pMHC) and a CD4 or CD8 molecule which bind to a conserved region of that same MHC gene product (class II or I, respectively). Structural biology has since precisely revealed those bidentate pMHC interactions. TCR?? ligates the membrane-distal antigen binding MHC platform whereas CD8 clamps a membrane-proximal MHCI ?3 domain loop and CD4 docks to a hydrophobic crevice between MHCII ?2 and ?2 domains. We review how MHC class-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conformational transitions that may optimally expose the co-receptor docking site on MHC. Twit Text FOAVip Codification of bidentate pMHC interaction with TCR and co-receptor ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25818864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25818864 #FOAvip English Wikipedia <ref>{{Cite pmid|25818864}}</ref> Codification of bidentate pMHC interaction with TCR and co-receptor #MMPMID25818864 Reinherz EL; Wang Jh Trends Immunol 2015[May]; 36 (5): 300-6 PMID25818864show ga A 1983 Immunology Today rostrum hypothesized that each T cell has two recognition units: a TCR complex which binds antigen associated with a polymorphic region of an MHC molecule (pMHC) and a CD4 or CD8 molecule which bind to a conserved region of that same MHC gene product (class II or I, respectively). Structural biology has since precisely revealed those bidentate pMHC interactions. TCR?? ligates the membrane-distal antigen binding MHC platform whereas CD8 clamps a membrane-proximal MHCI ?3 domain loop and CD4 docks to a hydrophobic crevice between MHCII ?2 and ?2 domains. We review how MHC class-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conformational transitions that may optimally expose the co-receptor docking site on MHC. äCodification of bidentate pMHC interaction with TCR and co-receptor (epmc).pdf DeepDyve Pubget Overpricing