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10.1182/asheducation-2014.1.71 http://scihub22266oqcxt.onion/10.1182/asheducation-2014.1.71 C4419374!4419374!25696837     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hematology+Am+Soc+Hematol+Educ+Program 2014 ; 2014 (1): 71-6 Nephropedia Template TP {{tp|p=25696837|t=2014. Biology of Marrow Failure Syndromes: Role of Microenvironment and Niches |pdf=|usr=}}{{25696837}} gab.com Text Biology of Marrow Failure Syndromes: Role of Microenvironment and Niches JO: Hematology Am Soc Hematol Educ Program http://www.kidney.de/pget.php?&tw=1&pmid=25696837 #FOAvip The marrow microenvironment and its components regulate hematopoietic stem and progenitor cell (HSC) fate. An abnormality in the marrow microenvironment and specific dysfunction of the HSC niche could play a critical role in initiation, disease progression and response to therapy of marrow failure syndromes. Therefore, the identification of changes in the HSC niche in marrow failure syndromes should lead to further knowledge of the signals that disrupt the normal microenvironment. In turn, niche disruption may contribute to disease morbidity resulting in pancytopenia and clonal evolution, and its understanding could point to new therapeutic targets for these conditions. We briefly (a) review evidence for the importance of the marrow microenvironment as a regulator of normal hematopoiesis, (b) summarize the current knowledge regarding the role of dysfunctions in the marrow microenvironment in marrow failure syndromes, and (c) propose a strategy through which niche stimulation can complement current treatment for MDS. Twit Text FOAVip Biology of Marrow Failure Syndromes: Role of Microenvironment and Niches ????Hematology Am Soc Hematol Educ Program http://www.kidney.de/pget.php?&tw=1&pmid=25696837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25696837 #FOAvip English Wikipedia <ref>{{Cite pmid|25696837}}</ref> Biology of Marrow Failure Syndromes: Role of Microenvironment and Niches #MMPMID25696837 Balderman SR; Calvi LM Hematology Am Soc Hematol Educ Program 2014[Dec]; 2014 (1): 71-6 PMID25696837show ga The marrow microenvironment and its components regulate hematopoietic stem and progenitor cell (HSC) fate. An abnormality in the marrow microenvironment and specific dysfunction of the HSC niche could play a critical role in initiation, disease progression and response to therapy of marrow failure syndromes. Therefore, the identification of changes in the HSC niche in marrow failure syndromes should lead to further knowledge of the signals that disrupt the normal microenvironment. In turn, niche disruption may contribute to disease morbidity resulting in pancytopenia and clonal evolution, and its understanding could point to new therapeutic targets for these conditions. We briefly (a) review evidence for the importance of the marrow microenvironment as a regulator of normal hematopoiesis, (b) summarize the current knowledge regarding the role of dysfunctions in the marrow microenvironment in marrow failure syndromes, and (c) propose a strategy through which niche stimulation can complement current treatment for MDS. äBiology of Marrow Failure Syndromes: Role of Microenvironment and Nich(epmc).pdf DeepDyve Pubget Overpricing