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2015 ; 185
(5
): 1172-84
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The role of formylated peptides and formyl peptide receptor 1 in governing
neutrophil function during acute inflammation
#MMPMID25791526
Dorward DA
; Lucas CD
; Chapman GB
; Haslett C
; Dhaliwal K
; Rossi AG
Am J Pathol
2015[May]; 185
(5
): 1172-84
PMID25791526
show ga
Neutrophil migration to sites of inflammation and the subsequent execution of
multiple functions are designed to contain and kill invading pathogens. These
highly regulated and orchestrated processes are controlled by interactions
between numerous receptors and their cognate ligands. Unraveling and identifying
those that are central to inflammatory processes may represent novel therapeutic
targets for the treatment of neutrophil-dominant inflammatory disorders in which
dysregulated neutrophil recruitment, function, and elimination serve to
potentiate rather than resolve an initial inflammatory insult. The first G
protein-coupled receptor to be described on human neutrophils, formyl peptide
receptor 1 (FPR1), is one such receptor that plays a significant role in the
execution of these functions through multiple intracellular signaling pathways.
Recent work has highlighted important observations with regard to both receptor
function and the importance and functional relevance of FPR1 in the pathogenesis
of a range of both sterile and infective inflammatory conditions. In this review,
we explore the multiple components of neutrophil migration and function in both
health and disease, with a focus on the role of FPR1 in these processes. The
current understanding of FPR1 structure, function, and signaling is examined,
alongside discussion of the potential importance of FPR1 in inflammatory diseases
suggesting that FPR1 is a key regulator of the inflammatory environment.
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