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10.1007/s11999-014-3774-8 http://scihub22266oqcxt.onion/10.1007/s11999-014-3774-8 C4418989!4418989 !25024024     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25024024 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Orthop+Relat+Res 2015 ; 473 (6 ): 1903-12 Nephropedia Template TP {{tp|p=25024024 |t=2015. Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? |pdf=|usr=}}{{25024024 }} gab.com Text Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions JO: Clin Orthop Relat Res http://www.kidney.de/pget.php?&tw=1&pmid=25024024 #FOAvip BACKGROUND: Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but current investigations seek to clarify the underlying process and offer new treatment options. It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration. In this review, we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration. RESULTS: A healthy disc requires maintenance of a homeostatic environment, and when disrupted, a catabolic cascade of events occurs on a molecular level resulting in upregulation of proinflammatory cytokines, increased degradative enzymes, and a loss of matrix proteins. This promotes degenerative changes and occasional neurovascular ingrowth potentially contributing to the development of pain. Research demonstrates the molecular changes underlying the harmful effects of aging, smoking, and obesity seen clinically while demonstrating the variable influence of exercise. Finally, oral medications, supplements, biologic treatments, gene therapy, and stem cells hold great promise but require cautious application until their safety profiles are better outlined. CONCLUSIONS: Intervertebral disc degeneration occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians because it may help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies. Twit Text FOAVip Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions ????Clin Orthop Relat Res http://www.kidney.de/pget.php?&tw=1&pmid=25024024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25024024 #FOAvip English Wikipedia <ref>{{Cite pmid|25024024 }}</ref> Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? #MMPMID25024024 Kadow T ; Sowa G ; Vo N ; Kang JD Clin Orthop Relat Res 2015[Jun]; 473 (6 ): 1903-12 PMID25024024 show ga BACKGROUND: Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but current investigations seek to clarify the underlying process and offer new treatment options. It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration. In this review, we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration. RESULTS: A healthy disc requires maintenance of a homeostatic environment, and when disrupted, a catabolic cascade of events occurs on a molecular level resulting in upregulation of proinflammatory cytokines, increased degradative enzymes, and a loss of matrix proteins. This promotes degenerative changes and occasional neurovascular ingrowth potentially contributing to the development of pain. Research demonstrates the molecular changes underlying the harmful effects of aging, smoking, and obesity seen clinically while demonstrating the variable influence of exercise. Finally, oral medications, supplements, biologic treatments, gene therapy, and stem cells hold great promise but require cautious application until their safety profiles are better outlined. CONCLUSIONS: Intervertebral disc degeneration occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians because it may help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies. |Extracellular Matrix Proteins/metabolism [MESH] |Humans [MESH] |Inflammation Mediators/metabolism [MESH] |Intervertebral Disc Degeneration/diagnosis/*metabolism/physiopathology/therapy [MESH] |Intervertebral Disc Displacement/diagnosis/*metabolism/physiopathology/therapy [MESH] |Intervertebral Disc/*metabolism/pathology/physiopathology [MESH] |Orthopedic Procedures [MESH] |Peptide Hydrolases/metabolism [MESH] |Predictive Value of Tests [MESH] |Risk Factors [MESH] |Signal Transduction [MESH]Molecular basis of intervertebral disc degeneration and herniations: w(epmc).pdf DeepDyve Pubget Overpricing