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2014 ; 21
(5
): 30-6
Nephropedia Template TP
gab.com Text
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English Wikipedia
Relationship between Intracellular Magnesium Level, Lung Function, and Level of
Asthma Control in Children with Chronic Bronchial Asthma
#MMPMID25977631
Sein HH
; Whye Lian C
; Juan Loong K
; Sl Ng J
; Rahardjai A
; Sultan MA
Malays J Med Sci
2014[Sep]; 21
(5
): 30-6
PMID25977631
show ga
BACKGROUND: This study aimed to determine the intracellular (red blood cell
(RBC)) magnesium levels in children with chronic bronchial asthma and to
determine the relationship between the magnesium level and peak expiratory flow
rate (PEFR), type of asthma treatment, and level of asthma control. METHODS: A
cross-sectional study was conducted at the Paediatric Clinic, Sarawak General
Hospital. A total of 100 children, aged 6-12 years with chronic bronchial asthma,
were recruited according to the study criteria. Venous blood samples were
obtained to measure the intracellular (RBC) magnesium level using the GBC Avanta
Flame Atomic Absorption Spectrophotometer. RESULTS: Mean age was 8.57 (SD 1.18)
years, and 63% of the participants were male. Mean duration of asthma was 62.2
(SD 32.3) months. A normal intracellular magnesium level was found in 95% of the
participants, with a mean of 2.27 (SD 0.33) mmol/L. Two-thirds of the
participants had a normal peak flow expiratory rate (> 80% of predicted value).
About 85% were using both reliever and controller. Almost half of the
participants (49%) had chronic asthma that was well-controlled. No significant
relationship was found between magnesium level and age (r = -0.089, P = 0.379),
gender (t = 0.64, P = 0.52), duration of asthma (r = -0.03, P = 0.74), PEFR (t =
0.41, P = 0.68), current level of asthma control (t = 0.02, P = 0.97), and
current treatment (t = 0.414, P = 0.680). CONCLUSION: There was no significant
intracellular magnesium deficiency in children with chronic bronchial asthma.
There was no significant relationship between therapeutic medications used for
treatment of children with chronic asthma and intracellular magnesium levels.