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10.4049/jimmunol.1400560 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400560 C4417450!4417450!25870237     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (10): 4698-704 Nephropedia Template TP {{tp|p=25870237|t=2015. Recycled interleukin-7 can be delivered to neighboring T cells |pdf=|usr=}}{{25870237}} gab.com Text Recycled interleukin-7 can be delivered to neighboring T cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25870237 #FOAvip Interleukin-7 (IL-7) is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo. Here, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine ?recycling? during which T cells treated with rIL-7 are rapidly induced to express P-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7 receptor alpha chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions prior to recycling. These observations provide evidence of a novel mechanism that enables cells to optimally utilize IL-7. Twit Text FOAVip Recycled interleukin-7 can be delivered to neighboring T cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25870237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25870237 #FOAvip English Wikipedia <ref>{{Cite pmid|25870237}}</ref> Recycled interleukin-7 can be delivered to neighboring T cells #MMPMID25870237 Bazdar DA; Kalinowska M; Panigrahi S; Sieg SF J Immunol 2015[May]; 194 (10): 4698-704 PMID25870237show ga Interleukin-7 (IL-7) is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo. Here, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine ?recycling? during which T cells treated with rIL-7 are rapidly induced to express P-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7 receptor alpha chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions prior to recycling. These observations provide evidence of a novel mechanism that enables cells to optimally utilize IL-7. äRecycled interleukin-7 can be delivered to neighboring T cells (epmc).pdf DeepDyve Pubget Overpricing